Promysalin is a salicylate-containing antimicrobial with a cell-membrane-disrupting mechanism of action on Gram-positive bacteria

Rahul D. Kaduskar, Giulia Della Scala, Zaaima J.H. Al Jabri, Stefania Arioli, Loana Musso, Marco R. Oggioni, Sabrina Dallavalle, Diego Mora

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Promysalin was previously described as a narrow spectrum molecule with a unique species-specific activity against Pseudomonas aeruginosa. Here we demonstrate that promysalin is active against Gram-positive and Gram-negative bacteria using a microdilution assay. Promysalin acts on Gram-positive bacteria with a mechanism of action involving cell membrane damage with leakage of intracellular components. The evaluation of MICs and MBCs on 11 promysalin analogs, synthesized utilizing diverted total synthesis, allowed the identification of the structural moieties potentially involved in cell membrane interaction and damage. The mechanism of action of promysalin against Gram-negative bacteria is still not clarified, even if a synergistic effect with the bisguanidine chlorhexidine on cell membrane disruption has been observed.

Original languageEnglish
Article number8861
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Salicylates
Gram-Positive Bacteria
Cell Membrane
Gram-Negative Bacteria
Chlorhexidine
Cell Communication
Pseudomonas aeruginosa
promysalin

ASJC Scopus subject areas

  • General

Cite this

Promysalin is a salicylate-containing antimicrobial with a cell-membrane-disrupting mechanism of action on Gram-positive bacteria. / Kaduskar, Rahul D.; Scala, Giulia Della; Al Jabri, Zaaima J.H.; Arioli, Stefania; Musso, Loana; Oggioni, Marco R.; Dallavalle, Sabrina; Mora, Diego.

In: Scientific Reports, Vol. 7, No. 1, 8861, 01.12.2017.

Research output: Contribution to journalArticle

Kaduskar, Rahul D. ; Scala, Giulia Della ; Al Jabri, Zaaima J.H. ; Arioli, Stefania ; Musso, Loana ; Oggioni, Marco R. ; Dallavalle, Sabrina ; Mora, Diego. / Promysalin is a salicylate-containing antimicrobial with a cell-membrane-disrupting mechanism of action on Gram-positive bacteria. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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AU - Arioli, Stefania

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AU - Oggioni, Marco R.

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