Prolactin receptor expression by lymphoid tissues in normal and immunized rats

Crystal Y. Koh, J. Theodore Phillips

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Prolactin receptor (PRLr) expression and distribution in thymus, spleen, bone marrow, lymph nodes, and peripheral blood lymphocytes from young adult Lewis rats are analyzed using single-color flow cytometry and a well-characterized monoclonal antibody directed against the rat liver PRLr. The in vivo effects of regional immunization on PRLr expression are also examined. PRLr is found to be widely distributed among cells of the immune system and demonstrates lymphoid tissue-specific patterns of expression. Footpad immunization caused the rapid, but transient, induction of PRLr expression in the draining lymph node, with only modest effects on PRLr expression in other distant lymphoid tissues. These studies indicate that PRL may be capable of direct interaction with the immune system through differential expression of the PRL cell surface receptor on select lymphoid target cell populations.

Original languageEnglish
JournalMolecular and Cellular Endocrinology
Volume92
Issue number2
DOIs
Publication statusPublished - 1993

    Fingerprint

Keywords

  • (Rat)
  • Anti-receptor antibody
  • Flow cytometry
  • Lymphocyte
  • Prolactin receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this