Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection

Gaëlle Breton, Nicolas Chomont, Hiroshi Takata, Rémi Fromentin, Jeffrey Ahlers, Abdelali Filali-Mouhim, Catherine Riou, Mohamed Rachid Boulassel, Jean Pierre Routy, Bader Yassine-Diab, Rafick Pierre Sékaly

Research output: Contribution to journalArticle

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Abstract

Chronic activation of T cells is a hallmark of HIV-1 infection and plays an important role in disease progression. We previously showed that the engagement of the inhibitory receptor programmed death (PD)-1 on HIV-1-specific CD4 + and CD8+ T cells leads to their functional exhaustion in vitro. However, little is known about the impact of PD-1 expression on the turnover and maturation status of T cells during the course of the disease. In this study, we show that PD-1 is upregulated on all T cell subsets, including naive, central memory, and transitional memory T cells in HIV-1-infected subjects. PD-1 is expressed at similar levels on most CD4+ T cells during the acute and the chronic phase of disease and identifies cells that have recently entered the cell cycle. In contrast, PD-1 expression is dramatically increased in CD8+ T cells during the transition from acute to chronic infection, and this is associated with reduced levels of cell proliferation. The failure to downregulate expression of PD-1 in most T cells during chronic HIV-1 infection is associated with persistent alterations in the distribution of T cell subsets and is associated with impaired responses to IL-7. Our findings identify PD-1 as a marker for aberrant distribution of T cell subsets in HIV-1 infection.

Original languageEnglish
Pages (from-to)2194-2204
Number of pages11
JournalJournal of Immunology
Volume191
Issue number5
DOIs
Publication statusPublished - Sep 1 2013

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T-Lymphocyte Subsets
HIV Infections
HIV-1
T-Lymphocytes
Interleukin-7
Death Domain Receptors
Disease Progression
Cell Cycle
Chronic Disease
Down-Regulation
Cell Proliferation
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Breton, G., Chomont, N., Takata, H., Fromentin, R., Ahlers, J., Filali-Mouhim, A., ... Sékaly, R. P. (2013). Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection. Journal of Immunology, 191(5), 2194-2204. https://doi.org/10.4049/jimmunol.1200646

Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection. / Breton, Gaëlle; Chomont, Nicolas; Takata, Hiroshi; Fromentin, Rémi; Ahlers, Jeffrey; Filali-Mouhim, Abdelali; Riou, Catherine; Boulassel, Mohamed Rachid; Routy, Jean Pierre; Yassine-Diab, Bader; Sékaly, Rafick Pierre.

In: Journal of Immunology, Vol. 191, No. 5, 01.09.2013, p. 2194-2204.

Research output: Contribution to journalArticle

Breton, G, Chomont, N, Takata, H, Fromentin, R, Ahlers, J, Filali-Mouhim, A, Riou, C, Boulassel, MR, Routy, JP, Yassine-Diab, B & Sékaly, RP 2013, 'Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection', Journal of Immunology, vol. 191, no. 5, pp. 2194-2204. https://doi.org/10.4049/jimmunol.1200646
Breton, Gaëlle ; Chomont, Nicolas ; Takata, Hiroshi ; Fromentin, Rémi ; Ahlers, Jeffrey ; Filali-Mouhim, Abdelali ; Riou, Catherine ; Boulassel, Mohamed Rachid ; Routy, Jean Pierre ; Yassine-Diab, Bader ; Sékaly, Rafick Pierre. / Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection. In: Journal of Immunology. 2013 ; Vol. 191, No. 5. pp. 2194-2204.
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