Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer

Ahmed K. Al-Shukaili, Ali A. Al-Jabri, Mansour S. Al-Moundhari

Research output: Contribution to journalArticle

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Abstract

Objectives: To investigate the prevalence of a group of different autoantibodies, in Omani patients with gastric cancer, and to examine whether their presence correlates with clinical course of the disease. Methods: Ninety-three Omani patients with gastric cancer, and 100 gender-matched blood donors were investigated for the presence of 15 different auto-antibodies against nuclear antigens (ANA), extractible nuclear antigens (ENA), Scleroderma antigen (Scl-70), Sjogren syndrome antigen A/B (SSA/B), Smith antigen (Sm), ribonucleoprotein (RNP), Jo-1 antigen, double stranded DNA (ds-DNA), parietal cell antibodies (APCA), reticulin antibodies (ARA), smooth muscle antibodies (ASMA), proteinase 3 (PR3), myeloperoxidase (MPO), and mitochondria antibody (AMA). Antinuclear antigen were detected using human epithelial cells-2 (Hep-2 cells). Anti-dsDNA antibodies were measured using Crithidia lucilia slides; APCA, ARA, and ASMA were examined using mouse liver, kidney, and stomach sections. Other autoantibodies were detected using commercially available ELISA kits. Seventy-three out of the 93 patients with gastric cancer were divided into 4 groups (stages I to IV) according to disease severity. This study was conducted in the period of 2001-2005 in the Department of Microbiology and Immunology Laboratories of the College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Results: Approximately 40% of the autoantibodies investigated were found to be significantly higher in patients with gastric cancer than in normal controls. These autoantibodies are ANA (57.3 versus 14%, p

Original languageEnglish
Pages (from-to)1873-1877
Number of pages5
JournalSaudi Medical Journal
Volume27
Issue number12
Publication statusPublished - Dec 2006

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Stomach Neoplasms
Antibodies
Serum
Autoantibodies
Nuclear Antigens
Reticulin
Antigens
Smooth Muscle
Histidine-tRNA Ligase
Crithidia
Myeloblastin
Oman
Ribonucleoproteins
DNA
Microbiology
Allergy and Immunology
Blood Donors
Peroxidase
Anti-Idiotypic Antibodies
Stomach

ASJC Scopus subject areas

  • Medicine(all)

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Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer. / Al-Shukaili, Ahmed K.; Al-Jabri, Ali A.; Al-Moundhari, Mansour S.

In: Saudi Medical Journal, Vol. 27, No. 12, 12.2006, p. 1873-1877.

Research output: Contribution to journalArticle

Al-Shukaili, Ahmed K. ; Al-Jabri, Ali A. ; Al-Moundhari, Mansour S. / Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer. In: Saudi Medical Journal. 2006 ; Vol. 27, No. 12. pp. 1873-1877.
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