Probing Interactions Between Small Molecules and Polymers by Means of NMR Spectroscopy

Sara Cozzolino, Paolo Sequi, Massimiliano Valentini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Interactions between small molecules and polymers, or species with a biological relevance as proteins and enzymes, are of high significance in several research fields, above all physics, chemistry, biology and medicine. The type and the strength of the interactions rule most of the occurring processes and determine the main characteristics of the systems. Drug-receptor, signal transduction, cellular recognition are only a few examples of binding phenomena where a profound understanding of the interaction is indispensable. In the next pages, a brief overview of known application of NMR spectroscopy for assessing interactions between small molecules and polymers is reported with the aim of underlying the importance of NMR in this research area.

Original languageEnglish
Pages (from-to)181-213
Number of pages33
JournalAnnual Reports on NMR Spectroscopy
Volume74
DOIs
Publication statusPublished - 2011

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Keywords

  • Binding affinity
  • H-bonding
  • NMR pulse sequence
  • Preferred sites

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Spectroscopy

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