Probing Interactions Between Small Molecules and Polymers by Means of NMR Spectroscopy

Sara Cozzolino; Paolo Sequi; Massimiliano Valentini

doi:10.1016/B978-0-08-097072-1.00004-2

Probing Interactions Between Small Molecules and Polymers by Means of NMR Spectroscopy

Sara Cozzolino^*, Paolo Sequi, Massimiliano Valentini

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Interactions between small molecules and polymers, or species with a biological relevance as proteins and enzymes, are of high significance in several research fields, above all physics, chemistry, biology and medicine. The type and the strength of the interactions rule most of the occurring processes and determine the main characteristics of the systems. Drug-receptor, signal transduction, cellular recognition are only a few examples of binding phenomena where a profound understanding of the interaction is indispensable. In the next pages, a brief overview of known application of NMR spectroscopy for assessing interactions between small molecules and polymers is reported with the aim of underlying the importance of NMR in this research area.

Original language	English
Pages (from-to)	181-213
Number of pages	33
Journal	Annual Reports on NMR Spectroscopy
Volume	74
DOIs	https://doi.org/10.1016/B978-0-08-097072-1.00004-2
Publication status	Published - 2011

Keywords

Binding affinity
H-bonding
NMR pulse sequence
Preferred sites

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Spectroscopy

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10.1016/B978-0-08-097072-1.00004-2

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title = "Probing Interactions Between Small Molecules and Polymers by Means of NMR Spectroscopy",

abstract = "Interactions between small molecules and polymers, or species with a biological relevance as proteins and enzymes, are of high significance in several research fields, above all physics, chemistry, biology and medicine. The type and the strength of the interactions rule most of the occurring processes and determine the main characteristics of the systems. Drug-receptor, signal transduction, cellular recognition are only a few examples of binding phenomena where a profound understanding of the interaction is indispensable. In the next pages, a brief overview of known application of NMR spectroscopy for assessing interactions between small molecules and polymers is reported with the aim of underlying the importance of NMR in this research area.",

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AU - Cozzolino, Sara

AU - Sequi, Paolo

AU - Valentini, Massimiliano

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Y1 - 2011

N2 - Interactions between small molecules and polymers, or species with a biological relevance as proteins and enzymes, are of high significance in several research fields, above all physics, chemistry, biology and medicine. The type and the strength of the interactions rule most of the occurring processes and determine the main characteristics of the systems. Drug-receptor, signal transduction, cellular recognition are only a few examples of binding phenomena where a profound understanding of the interaction is indispensable. In the next pages, a brief overview of known application of NMR spectroscopy for assessing interactions between small molecules and polymers is reported with the aim of underlying the importance of NMR in this research area.

AB - Interactions between small molecules and polymers, or species with a biological relevance as proteins and enzymes, are of high significance in several research fields, above all physics, chemistry, biology and medicine. The type and the strength of the interactions rule most of the occurring processes and determine the main characteristics of the systems. Drug-receptor, signal transduction, cellular recognition are only a few examples of binding phenomena where a profound understanding of the interaction is indispensable. In the next pages, a brief overview of known application of NMR spectroscopy for assessing interactions between small molecules and polymers is reported with the aim of underlying the importance of NMR in this research area.

KW - Binding affinity

KW - H-bonding

KW - NMR pulse sequence

KW - Preferred sites

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EP - 213

JO - Annual Reports on NMR Spectroscopy

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SN - 0066-4103

ER -

Probing Interactions Between Small Molecules and Polymers by Means of NMR Spectroscopy

Abstract

Keywords

ASJC Scopus subject areas

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