Abstract
Interactions between small molecules and polymers, or species with a biological relevance as proteins and enzymes, are of high significance in several research fields, above all physics, chemistry, biology and medicine. The type and the strength of the interactions rule most of the occurring processes and determine the main characteristics of the systems. Drug-receptor, signal transduction, cellular recognition are only a few examples of binding phenomena where a profound understanding of the interaction is indispensable. In the next pages, a brief overview of known application of NMR spectroscopy for assessing interactions between small molecules and polymers is reported with the aim of underlying the importance of NMR in this research area.
| Original language | English |
|---|---|
| Pages (from-to) | 181-213 |
| Number of pages | 33 |
| Journal | Annual Reports on NMR Spectroscopy |
| Volume | 74 |
| DOIs | |
| Publication status | Published - 2011 |
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Keywords
- Binding affinity
- H-bonding
- NMR pulse sequence
- Preferred sites
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Spectroscopy
Cite this
Probing Interactions Between Small Molecules and Polymers by Means of NMR Spectroscopy. / Cozzolino, Sara; Sequi, Paolo; Valentini, Massimiliano.
In: Annual Reports on NMR Spectroscopy, Vol. 74, 2011, p. 181-213.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Probing Interactions Between Small Molecules and Polymers by Means of NMR Spectroscopy
AU - Cozzolino, Sara
AU - Sequi, Paolo
AU - Valentini, Massimiliano
PY - 2011
Y1 - 2011
N2 - Interactions between small molecules and polymers, or species with a biological relevance as proteins and enzymes, are of high significance in several research fields, above all physics, chemistry, biology and medicine. The type and the strength of the interactions rule most of the occurring processes and determine the main characteristics of the systems. Drug-receptor, signal transduction, cellular recognition are only a few examples of binding phenomena where a profound understanding of the interaction is indispensable. In the next pages, a brief overview of known application of NMR spectroscopy for assessing interactions between small molecules and polymers is reported with the aim of underlying the importance of NMR in this research area.
AB - Interactions between small molecules and polymers, or species with a biological relevance as proteins and enzymes, are of high significance in several research fields, above all physics, chemistry, biology and medicine. The type and the strength of the interactions rule most of the occurring processes and determine the main characteristics of the systems. Drug-receptor, signal transduction, cellular recognition are only a few examples of binding phenomena where a profound understanding of the interaction is indispensable. In the next pages, a brief overview of known application of NMR spectroscopy for assessing interactions between small molecules and polymers is reported with the aim of underlying the importance of NMR in this research area.
KW - Binding affinity
KW - H-bonding
KW - NMR pulse sequence
KW - Preferred sites
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U2 - 10.1016/B978-0-08-097072-1.00004-2
DO - 10.1016/B978-0-08-097072-1.00004-2
M3 - Article
VL - 74
SP - 181
EP - 213
JO - Annual Reports on NMR Spectroscopy
JF - Annual Reports on NMR Spectroscopy
SN - 0066-4103
ER -