Primary Pseudomonas meningitis in an adult, splenectomized, multitransfused thalassaemia major patient

K. Ghosh, S. Daar, D. Hiwase, N. Nusrat

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 19-year-old splenectomized, multitransfused female patient with β-thalassaemia major developed primary meningitis due to P. putida. Her blood cultures were negative. P. putida is an unusual nosocomial organism to cause primary meningitis. Infection due to this organism carries high mortality. However, owing to early diagnosis and energetic treatment this patient survived without any sequelae. A review of serious infections over the last 7 years in patients in our thalassaemia care centre revealed 11 serious infections among our splenectomized patients (n = 46) and none in the non-splenectomized group (n = 106). Surprisingly, all overwhelming infections (23.8% in the splenectomized group) were caused by Gram-negative bacilli like Klebsiella, Pseudomonas, Aeromonas and Campylobacter species. As all our splenectomized patients had prior pneumococcal vaccination and oral penicillin prophylaxis, overwhelming septicaemia due to S. Pneumoniae was successfully prevented, but an increasing incidence of overwhelming sepsis due to Gram-negative bacilli, against which no vaccination or suitable prophylactic antibiotics are available, is now posing a new threat to this vulnerable group of patients.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalHaematologia
Volume30
Issue number1
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

beta-Thalassemia
Pseudomonas
Meningitis
Infection
Bacillus
Sepsis
Vaccination
Aeromonas
Campylobacter
Thalassemia
Klebsiella
Penicillins
Early Diagnosis
Pneumonia
Anti-Bacterial Agents
Mortality
Incidence

Keywords

  • Iron overload
  • Primary meningitis
  • Pseudomonas putida
  • Splenectomy
  • Thalassaemia major

ASJC Scopus subject areas

  • Hematology

Cite this

Primary Pseudomonas meningitis in an adult, splenectomized, multitransfused thalassaemia major patient. / Ghosh, K.; Daar, S.; Hiwase, D.; Nusrat, N.

In: Haematologia, Vol. 30, No. 1, 2000, p. 69-72.

Research output: Contribution to journalArticle

Ghosh, K, Daar, S, Hiwase, D & Nusrat, N 2000, 'Primary Pseudomonas meningitis in an adult, splenectomized, multitransfused thalassaemia major patient', Haematologia, vol. 30, no. 1, pp. 69-72.
Ghosh, K. ; Daar, S. ; Hiwase, D. ; Nusrat, N. / Primary Pseudomonas meningitis in an adult, splenectomized, multitransfused thalassaemia major patient. In: Haematologia. 2000 ; Vol. 30, No. 1. pp. 69-72.
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