TY - JOUR
T1 - Prevalence of human papilloma virus in Oman
T2 - Genotypes 82 and 68 are dominating
AU - Al-Lawati, Zainab
AU - Khamis, Faryal A.
AU - Al-Hamdani, Aisha
AU - Al-Kalbani, Moza
AU - Ramadhan, Fatma Ali
AU - Al-Rawahi, Thuria Rashid
AU - Al-Kobaisi, Muhannad F.
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/4
Y1 - 2020/4
N2 - Background: Persistent infection with high-risk (HR) HPV genotypes has been associated with cervical cancer, the third cancer affecting women in Oman with a crude incidence rate of 4.7 and mortality rate of 2.5 respectively. Other types of lower-risk (LR) HPV are associated with warts in both genders worldwide. Objectives: To assess the prevalence and genotype distribution of HPV and the risk factors among women with normal and abnormal cytology. Methods: A cross sectional study conducted between September 2014 and April 2015. 258 cervical samples were obtained from women aged 18–68 years attending the Gynaecology Out-patient Clinic. HPV genotyping was performed using a multiplex real time-polymerase chain reaction (RT-PCR) assay. Results: 22 different HPV genotypes were detected in 46 women (17.8%) and included 15 HR and 7 LR genotypes. Human immunodeficiency virus (HIV) patients (P = 0.052) and oral contraceptives users (P = 0.016) showed significant association with HPV infection. Conclusion: The most frequently observed HPV types were HR HPV 82 and LR HPV 54. These findings show that the predominant HPV genotypes in Oman are different from those seen in worldwide studies. This finding is important to determine the potential impact of preventive measures especially new vaccines to reduce the burden of cervical cancer.
AB - Background: Persistent infection with high-risk (HR) HPV genotypes has been associated with cervical cancer, the third cancer affecting women in Oman with a crude incidence rate of 4.7 and mortality rate of 2.5 respectively. Other types of lower-risk (LR) HPV are associated with warts in both genders worldwide. Objectives: To assess the prevalence and genotype distribution of HPV and the risk factors among women with normal and abnormal cytology. Methods: A cross sectional study conducted between September 2014 and April 2015. 258 cervical samples were obtained from women aged 18–68 years attending the Gynaecology Out-patient Clinic. HPV genotyping was performed using a multiplex real time-polymerase chain reaction (RT-PCR) assay. Results: 22 different HPV genotypes were detected in 46 women (17.8%) and included 15 HR and 7 LR genotypes. Human immunodeficiency virus (HIV) patients (P = 0.052) and oral contraceptives users (P = 0.016) showed significant association with HPV infection. Conclusion: The most frequently observed HPV types were HR HPV 82 and LR HPV 54. These findings show that the predominant HPV genotypes in Oman are different from those seen in worldwide studies. This finding is important to determine the potential impact of preventive measures especially new vaccines to reduce the burden of cervical cancer.
KW - Abnormal cervical cytology
KW - Genotypes
KW - HPV prevalence
KW - High risk HPV
KW - Low risk HPV
KW - Normal cervical cytology
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U2 - 10.1016/j.ijid.2019.12.038
DO - 10.1016/j.ijid.2019.12.038
M3 - Article
C2 - 31935539
AN - SCOPUS:85079405574
SN - 1201-9712
VL - 93
SP - 22
EP - 27
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -