Prevalence and heritability of clusters for diagnostic components of metabolic syndrome

The Oman family study

Juan C. Lopez-Alvarenga, Carolina Solís-Herrera, Jack W. Kent, Deepali Jaju, Sulayma Albarwani, Saheed Al-Yahyahee, M. Osman Hassan, Riad Bayoumir, Anthony G. Comuzzie

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Prevalence and heritability of metabolic syndrome (MetS) vary between populations according to the currently used criteria. We examined combinations for joint probabilities and heritabilities of MetS criteria from the National Cholesterol Education Program Adult Treatment Panel III (NCEP), World Health Organization (WHO), and International Diabetes Federation (IDF) in a sample of Omani families. Methods: We included 1277 subjects from 5 pedigrees. The likelihood ratio of diagnostic cluster dependence over clustering by chance was LDep = P(dependent)/P(independent). Heritabilities were adjusted by sex and age. Results: The highest LDep were central obesity (CO) + high glucose level (HGl) + triglycerides (IDF, 3.08; NCEP, 4.38; WHO, 3.17; P <0.001). Triglycerides combined with any other component were the most common cluster. The lowest LDep for IDF were high blood pressure (HBP) + CO + low HDL-C (1.21, P <0.025); for NCEP were HBP + HGl + low HDL-C (1.21, P <0.07). These components were gathered almost by chance alone. In contrast, the lowest LDep for WHO were HGl + CO + low HDL-C (2.01, P <0.001). The WHO criteria yielded the highest heritability for a MetS diagnosis (h2 = 0.9), followed by NCEP (0.48) and IDF (0.38). The rationale of the MetS diagnostics is based on insulin resistance. This base would be lost if we continue lowering cut-off points for diagnosis for increasing the sensitivity. The WHO showed the highest values for LDep for all components because they used the highest cut-off points.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalMetabolic Syndrome and Related Disorders
Volume6
Issue number2
DOIs
Publication statusPublished - Jun 1 2008

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Oman
Abdominal Obesity
Glucose
Triglycerides
Hypertension
Pedigree
Cluster Analysis
Insulin Resistance
Cholesterol
Education
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Prevalence and heritability of clusters for diagnostic components of metabolic syndrome : The Oman family study. / Lopez-Alvarenga, Juan C.; Solís-Herrera, Carolina; Kent, Jack W.; Jaju, Deepali; Albarwani, Sulayma; Al-Yahyahee, Saheed; Hassan, M. Osman; Bayoumir, Riad; Comuzzie, Anthony G.

In: Metabolic Syndrome and Related Disorders, Vol. 6, No. 2, 01.06.2008, p. 129-135.

Research output: Contribution to journalArticle

Lopez-Alvarenga, JC, Solís-Herrera, C, Kent, JW, Jaju, D, Albarwani, S, Al-Yahyahee, S, Hassan, MO, Bayoumir, R & Comuzzie, AG 2008, 'Prevalence and heritability of clusters for diagnostic components of metabolic syndrome: The Oman family study', Metabolic Syndrome and Related Disorders, vol. 6, no. 2, pp. 129-135. https://doi.org/10.1089/met.2007.0039
Lopez-Alvarenga, Juan C. ; Solís-Herrera, Carolina ; Kent, Jack W. ; Jaju, Deepali ; Albarwani, Sulayma ; Al-Yahyahee, Saheed ; Hassan, M. Osman ; Bayoumir, Riad ; Comuzzie, Anthony G. / Prevalence and heritability of clusters for diagnostic components of metabolic syndrome : The Oman family study. In: Metabolic Syndrome and Related Disorders. 2008 ; Vol. 6, No. 2. pp. 129-135.
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AU - Jaju, Deepali

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AU - Al-Yahyahee, Saheed

AU - Hassan, M. Osman

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AU - Comuzzie, Anthony G.

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