Prevalence and covariates of polypharmacy in elderly patients on discharge from a tertiary care hospital in Oman

Amna Al-Hashar, Hamed Al Sinawi, Anwar Al Mahrizi, Manal Al-Hatrushi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: To evaluate the prevalence of polypharmacy in relation to gender, comorbidity, and age among elderly patients upon discharge from an academic tertiary care hospital in Muscat, Oman. Methods: This cross-sectional study was conducted at Sultan Qaboos University Hospital between February and July 2014. We reviewed the electronic medical records of elderly patients aged ≥ 60 years who were admitted to any of the hospital’s medical wards during the study period and collected data on age, gender, and diagnoses. We also collected information on the medications prescribed on discharge. Polypharmacy was defined as the concurrent use of ≥ 5 medications. Results: A total of 431 elderly inpatients were enrolled, of which approximately 50% were female. Polypharmacy was identified in 76.3% of discharge prescriptions. Gender (adjusted odds ratio (aOR), 1.17; 95% CI 0.73, 1.88, p = 0.502) and age (aOR, 0.98; 95% CI 0.95, 1.00, p = 0.075) had no impact on polypharmacy. On the other hand, a significant association between polypharmacy and comorbidity was observed (aOR, 1.31; 95% CI 1.12, 1.54, p = 0.001). Cardiovascular diagnosis on admission was also identified as being associated with polypharmacy (aOR, 2.66; 95% CI 1.49, 4.75, p = 0.001). More patients had cardiovascular diseases on admission (31.0%), followed by infections (23.0%), and gastrointestinal diseases (13.0%). The most commonly prescribed drugs on discharge were cardiovascular drugs (48.0%), followed by drugs acting on the gastrointestinal system (11.0%), endocrine system (9.2%), and nutrition and blood (7.5%). Conclusions: The prevalence of polypharmacy among elderly medical patients discharged from our hospital was high (76.3%) and was associated with a number of comorbidities and cardiovascular disease as a cause of admission, but not with age or gender. The prevalence of polypharmacy in our institution raises significant concerns over its potential impact on patients’ health outcomes and requires further investigation. Raising physicians’ awareness of health implications of polypharmacy may help reduce the incidence of medication-related adverse events and improve treatment outcomes.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalOman Medical Journal
Volume31
Issue number6
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Oman
Polypharmacy
Patient Discharge
Tertiary Healthcare
Tertiary Care Centers
Odds Ratio
Comorbidity
Cardiovascular Diseases
Cardiovascular Agents
Endocrine System
Electronic Health Records
Gastrointestinal Diseases
Health
Interpersonal Relations
Pharmaceutical Preparations
Prescriptions
Inpatients
Cross-Sectional Studies
Physicians

Keywords

  • Elderly
  • Inpatients
  • Medicines
  • Oman
  • Polypharmacy
  • Prevalence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevalence and covariates of polypharmacy in elderly patients on discharge from a tertiary care hospital in Oman. / Al-Hashar, Amna; Al Sinawi, Hamed; Al Mahrizi, Anwar; Al-Hatrushi, Manal.

In: Oman Medical Journal, Vol. 31, No. 6, 01.11.2016, p. 421-425.

Research output: Contribution to journalArticle

Al-Hashar, Amna ; Al Sinawi, Hamed ; Al Mahrizi, Anwar ; Al-Hatrushi, Manal. / Prevalence and covariates of polypharmacy in elderly patients on discharge from a tertiary care hospital in Oman. In: Oman Medical Journal. 2016 ; Vol. 31, No. 6. pp. 421-425.
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abstract = "Objectives: To evaluate the prevalence of polypharmacy in relation to gender, comorbidity, and age among elderly patients upon discharge from an academic tertiary care hospital in Muscat, Oman. Methods: This cross-sectional study was conducted at Sultan Qaboos University Hospital between February and July 2014. We reviewed the electronic medical records of elderly patients aged ≥ 60 years who were admitted to any of the hospital’s medical wards during the study period and collected data on age, gender, and diagnoses. We also collected information on the medications prescribed on discharge. Polypharmacy was defined as the concurrent use of ≥ 5 medications. Results: A total of 431 elderly inpatients were enrolled, of which approximately 50{\%} were female. Polypharmacy was identified in 76.3{\%} of discharge prescriptions. Gender (adjusted odds ratio (aOR), 1.17; 95{\%} CI 0.73, 1.88, p = 0.502) and age (aOR, 0.98; 95{\%} CI 0.95, 1.00, p = 0.075) had no impact on polypharmacy. On the other hand, a significant association between polypharmacy and comorbidity was observed (aOR, 1.31; 95{\%} CI 1.12, 1.54, p = 0.001). Cardiovascular diagnosis on admission was also identified as being associated with polypharmacy (aOR, 2.66; 95{\%} CI 1.49, 4.75, p = 0.001). More patients had cardiovascular diseases on admission (31.0{\%}), followed by infections (23.0{\%}), and gastrointestinal diseases (13.0{\%}). The most commonly prescribed drugs on discharge were cardiovascular drugs (48.0{\%}), followed by drugs acting on the gastrointestinal system (11.0{\%}), endocrine system (9.2{\%}), and nutrition and blood (7.5{\%}). Conclusions: The prevalence of polypharmacy among elderly medical patients discharged from our hospital was high (76.3{\%}) and was associated with a number of comorbidities and cardiovascular disease as a cause of admission, but not with age or gender. The prevalence of polypharmacy in our institution raises significant concerns over its potential impact on patients’ health outcomes and requires further investigation. Raising physicians’ awareness of health implications of polypharmacy may help reduce the incidence of medication-related adverse events and improve treatment outcomes.",
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