Presenting features, treatment patterns and outcomes of patients with breast cancer in Pakistan

Experience at a university hospital

S. Kumar, A. J. Shaikh, Y. A. Rashid, N. Masood, A. T V Mohammed, U. Z. Malik, G. Haider, N. Niamutullah, S. Khan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Breast cancer is the most common cancer in Pakistani women. We report the presenting features, treatment patterns and survival of breast cancer from a University Hospital in Southern Pakistan and compare the data with international population based studies. Materials and Methods: Medical records of patients diagnosed to have breast cancer between January 1999 and November 2008 were reviewed retrospectively. Results: A total of 845 patients were identified. Median age of diagnosis was 48 years (range 18-92). Clinical stage was as follows: Stage I 9.9%; Stage II 48.5%; Stage III 26.2%; Stage IV 13.8%; data not available 1.5%. Approximately, half (51.6%) were estrogen receptor (ER) positive and 17.5% over-expressed Her2/neu. Nearly 23% patients received neo-adjuvant chemotherapy while 68.9% received adjuvant chemotherapy. Anthracycline based treatment was the most common treatment until 2003 while later on, patients also received taxanes and trastuzumab based therapy. Age, stage, tumor size, lymph node status, tumor grade, ER status, treatment with hormonal therapy and radiation were the major predictive factors for overall survival (OS). We report an impressive 5 year OS of 75%, stage specific survival was 100%, 88% and 58% for Stages I, II and III respectively. Conclusion: The majority of patients present at a younger age and with locally advanced disease. However, short term follow-up reveals that the outcomes are comparable with the published literature from developed countries. Long-term follow-up and inclusion of data from population-based registries are required for accurate comparison.

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalIndian Journal of Cancer
Volume53
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Pakistan
Breast Neoplasms
Survival
Adjuvant Chemotherapy
Estrogen Receptors
Therapeutics
Taxoids
Neoplasms
Anthracyclines
Developed Countries
Population
Medical Records
Registries
Radiotherapy
Lymph Nodes

Keywords

  • Breast cancer
  • chemotherapy
  • Pakistan
  • presenting features
  • survival

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology

Cite this

Presenting features, treatment patterns and outcomes of patients with breast cancer in Pakistan : Experience at a university hospital. / Kumar, S.; Shaikh, A. J.; Rashid, Y. A.; Masood, N.; Mohammed, A. T V; Malik, U. Z.; Haider, G.; Niamutullah, N.; Khan, S.

In: Indian Journal of Cancer, Vol. 53, No. 2, 01.04.2016, p. 230-234.

Research output: Contribution to journalArticle

Kumar, S, Shaikh, AJ, Rashid, YA, Masood, N, Mohammed, ATV, Malik, UZ, Haider, G, Niamutullah, N & Khan, S 2016, 'Presenting features, treatment patterns and outcomes of patients with breast cancer in Pakistan: Experience at a university hospital', Indian Journal of Cancer, vol. 53, no. 2, pp. 230-234. https://doi.org/10.4103/0019-509X.197728
Kumar, S. ; Shaikh, A. J. ; Rashid, Y. A. ; Masood, N. ; Mohammed, A. T V ; Malik, U. Z. ; Haider, G. ; Niamutullah, N. ; Khan, S. / Presenting features, treatment patterns and outcomes of patients with breast cancer in Pakistan : Experience at a university hospital. In: Indian Journal of Cancer. 2016 ; Vol. 53, No. 2. pp. 230-234.
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