Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids

Sabira Begum; Syed Imran Hassan; Bina S. Siddiqui; Rehana Ifzal; Sobiya Perwaiz; Tahira Kiran; Farhana Shaheen; M. Nabeel Ghayur; Anwar H. Gilani

doi:10.1080/14786410512331330567

Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids

Sabira Begum^*, Syed Imran Hassan, Bina S. Siddiqui, Rehana Ifzal, Sobiya Perwaiz, Tahira Kiran, Farhana Shaheen, M. Nabeel Ghayur, Anwar H. Gilani

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Keeping in view the interesting chemistry and pharmacological importance of harmine series of bases - the β-carboline alkaloids, a number of new derivatives of tetrahydroharmine (1) and harmalol (2) have been prepared and characterized through spectral studies. Some of these derivatives showed spasmolytic activity. It was observed that all the N -acyl tetrahydroharmine derivatives are stable, not labile and no ring opening occurs in these compounds, as reported recently.

Original language	English
Pages (from-to)	213-227
Number of pages	15
Journal	Natural Product Research
Volume	20
Issue number	3
DOIs	https://doi.org/10.1080/14786410512331330567
Publication status	Published - Mar 2006
Externally published	Yes

Keywords

Acylation
Alkylation
Harmalol
Sulfonation
Tetrahydroharmine

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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title = "Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids",

abstract = "Keeping in view the interesting chemistry and pharmacological importance of harmine series of bases - the β-carboline alkaloids, a number of new derivatives of tetrahydroharmine (1) and harmalol (2) have been prepared and characterized through spectral studies. Some of these derivatives showed spasmolytic activity. It was observed that all the N -acyl tetrahydroharmine derivatives are stable, not labile and no ring opening occurs in these compounds, as reported recently.",

keywords = "Acylation, Alkylation, Harmalol, Sulfonation, Tetrahydroharmine",

author = "Sabira Begum and {Imran Hassan}, Syed and Siddiqui, {Bina S.} and Rehana Ifzal and Sobiya Perwaiz and Tahira Kiran and Farhana Shaheen and {Nabeel Ghayur}, M. and Gilani, {Anwar H.}",

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doi = "10.1080/14786410512331330567",

language = "English",

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T1 - Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids

AU - Begum, Sabira

AU - Imran Hassan, Syed

AU - Siddiqui, Bina S.

AU - Ifzal, Rehana

AU - Perwaiz, Sobiya

AU - Kiran, Tahira

AU - Shaheen, Farhana

AU - Nabeel Ghayur, M.

AU - Gilani, Anwar H.

PY - 2006/3

Y1 - 2006/3

N2 - Keeping in view the interesting chemistry and pharmacological importance of harmine series of bases - the β-carboline alkaloids, a number of new derivatives of tetrahydroharmine (1) and harmalol (2) have been prepared and characterized through spectral studies. Some of these derivatives showed spasmolytic activity. It was observed that all the N -acyl tetrahydroharmine derivatives are stable, not labile and no ring opening occurs in these compounds, as reported recently.

AB - Keeping in view the interesting chemistry and pharmacological importance of harmine series of bases - the β-carboline alkaloids, a number of new derivatives of tetrahydroharmine (1) and harmalol (2) have been prepared and characterized through spectral studies. Some of these derivatives showed spasmolytic activity. It was observed that all the N -acyl tetrahydroharmine derivatives are stable, not labile and no ring opening occurs in these compounds, as reported recently.

KW - Acylation

KW - Alkylation

KW - Harmalol

KW - Sulfonation

KW - Tetrahydroharmine

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U2 - 10.1080/14786410512331330567

DO - 10.1080/14786410512331330567

M3 - Article

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AN - SCOPUS:30844447724

SN - 1057-5634

VL - 20

SP - 213

EP - 227

JO - Natural Product Research

JF - Natural Product Research

IS - 3

ER -

Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids

Abstract

Keywords

ASJC Scopus subject areas

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