Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids

Sabira Begum, Syed Imran Hassan, Bina S. Siddiqui, Rehana Ifzal, Sobiya Perwaiz, Tahira Kiran, Farhana Shaheen, M. Nabeel Ghayur, Anwar H. Gilani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Keeping in view the interesting chemistry and pharmacological importance of harmine series of bases - the β-carboline alkaloids, a number of new derivatives of tetrahydroharmine (1) and harmalol (2) have been prepared and characterized through spectral studies. Some of these derivatives showed spasmolytic activity. It was observed that all the N -acyl tetrahydroharmine derivatives are stable, not labile and no ring opening occurs in these compounds, as reported recently.

Original languageEnglish
Pages (from-to)213-227
Number of pages15
JournalNatural Product Research
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Acylation
  • Alkylation
  • Harmalol
  • Sulfonation
  • Tetrahydroharmine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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    Begum, S., Imran Hassan, S., Siddiqui, B. S., Ifzal, R., Perwaiz, S., Kiran, T., Shaheen, F., Nabeel Ghayur, M., & Gilani, A. H. (2006). Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids. Natural Product Research, 20(3), 213-227. https://doi.org/10.1080/14786410512331330567