TY - JOUR
T1 - Predictive Value of Neutrophil to Lymphocyte Ratio in Outcomes of Patients with Acute Coronary Syndrome
AU - Muhmmed Suliman, Muhammed Abdul Rheem
AU - Bahnacy Juma, Abdullah Abdulaziz
AU - Ali Almadhani, Ali Ahmed
AU - Pathare, Anil Vasant
AU - Alkindi, Salam Salim Amur
AU - Uwe Werner, Fass
PY - 2010/11
Y1 - 2010/11
N2 - Background and Aims: Acute coronary syndrome (ACS) is associated with many hereditary and acquired predisposing factors. It has been recently shown that inflammation may play a role in myocardial ischemia. Hence, the white blood cell (WBC) count provides a simple and inexpensive method for assessment of inflammatory status in patients with ACS. An elevated WBC count has been associated with cardiovascular risk, but which leukocyte subtype carries this risk is uncertain. The aim of this study was to investigate the utility of admission neutrophil/lymphocyte ratio (NLR) in predicting the likelihood of poor outcomes in patients with ACS. Methods: A total of 300 consecutive patients admitted to the Internal Medicine Department, Sohar Hospital, Oman with the diagnosis of ACS from June 2008 to May 2009 were included in this study. Patients were divided into tertile groups according to the NLR. The primary end point was all-cause in-hospital mortality at the end of 30 days. Results: The mean age of patients included in this cohort was 61 years, with 63% of male patients. The mortality in the three groups based on NLR was 4, 10 and 19%, in the low-, middle- and high-risk groups, respectively (p <0.003; χ2 test). Conclusions: Admission NLR is clearly an independent predictor of all-cause mortality in patients with ACS.
AB - Background and Aims: Acute coronary syndrome (ACS) is associated with many hereditary and acquired predisposing factors. It has been recently shown that inflammation may play a role in myocardial ischemia. Hence, the white blood cell (WBC) count provides a simple and inexpensive method for assessment of inflammatory status in patients with ACS. An elevated WBC count has been associated with cardiovascular risk, but which leukocyte subtype carries this risk is uncertain. The aim of this study was to investigate the utility of admission neutrophil/lymphocyte ratio (NLR) in predicting the likelihood of poor outcomes in patients with ACS. Methods: A total of 300 consecutive patients admitted to the Internal Medicine Department, Sohar Hospital, Oman with the diagnosis of ACS from June 2008 to May 2009 were included in this study. Patients were divided into tertile groups according to the NLR. The primary end point was all-cause in-hospital mortality at the end of 30 days. Results: The mean age of patients included in this cohort was 61 years, with 63% of male patients. The mortality in the three groups based on NLR was 4, 10 and 19%, in the low-, middle- and high-risk groups, respectively (p <0.003; χ2 test). Conclusions: Admission NLR is clearly an independent predictor of all-cause mortality in patients with ACS.
KW - Acute coronary syndrome
KW - Inflammation
KW - Ischemia
KW - Neutrophil/lymphocyte ratio
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U2 - 10.1016/j.arcmed.2010.11.006
DO - 10.1016/j.arcmed.2010.11.006
M3 - Article
C2 - 21199731
AN - SCOPUS:78650742189
SN - 0188-4409
VL - 41
SP - 618
EP - 622
JO - Archives of Medical Research
JF - Archives of Medical Research
IS - 8
ER -