Potential effects of curcumin in the treatment of COVID-19 infection

Fatemeh Zahedipour, Seyede Atefe Hosseini, Thozhukat Sathyapalan, Muhammed Majeed, Tannaz Jamialahmadi, Khalid Al-Rasadi, Maciej Banach, Amirhossein Sahebkar*

*Corresponding author for this work

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2.

Original languageEnglish
JournalPhytotherapy Research
DOIs
Publication statusAccepted/In press - Jan 1 2020
Externally publishedYes

Keywords

  • acute respiratory distress syndrome
  • curcuminoids
  • pulmonary fibrosis
  • viral infection

ASJC Scopus subject areas

  • Pharmacology

Cite this

Zahedipour, F., Hosseini, S. A., Sathyapalan, T., Majeed, M., Jamialahmadi, T., Al-Rasadi, K., Banach, M., & Sahebkar, A. (Accepted/In press). Potential effects of curcumin in the treatment of COVID-19 infection. Phytotherapy Research. https://doi.org/10.1002/ptr.6738