Potential benefits of phytochemicals for abdominal aortic aneurysm

Azar Hosseini, Peter E. Penson, Arrigo F.G. Cicero, Jonathan Golledge, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Abdominal aortic aneurysms (AAAs) are a leading cause of death in older adults due to aortic rupture. There are currently no effective medical therapies for AAA, with surgery being the only acceptable treatment. There is frequently an extended period between AAA diagnosis and treatment by corrective surgery, during which an effective drug therapy could prevent or delay the need for AAA repair. Objec-tive: This review aimed to critically summarize prior research investigating the potential benefits of phytochemicals in preventing or treating AAA. Methods: In vitro, in vivo, and human studies examining the effect of phytochemicals in AAA models and patients were critically summarised. Results: Some preliminary data support the further investigation of curcumin, radix astra-gali, grape seed polyphenols, resveratrol, Ginkgo biloba extract (EGb 761), Ginsenoide Rb1, Dan Hong, Epigallocatechin-3-gallate, Baicalein, Fucoidan, Quercetin, and Sal-vianolic acid as potential treatments for AAA. Conclusion: Experimental in vivo and in vitro studies suggest the potential benefits of a number of medicinal herbs and phytochemicals in preventing or reducing the progression of AAA. In order to assess whether these findings can be translated into proven treat-ments, adequately designed double-blind randomized clinical trials will be required.

Original languageEnglish
Pages (from-to)8595-8607
Number of pages13
JournalCurrent Medicinal Chemistry
Volume28
Issue number41
DOIs
Publication statusPublished - Dec 2021
Externally publishedYes

Keywords

  • Abdominal aortic aneurysm
  • Inflammation
  • Oxidative stress
  • Phytochemi-cals
  • Phytotherapy
  • Plant medicine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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