Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa

Hamza A. Babiker; Jo Lines; William G. Hill; David Walliker

doi:10.4269/ajtmh.1997.56.141

Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa

Hamza A. Babiker^*, Jo Lines, William G. Hill, David Walliker

^*Corresponding author for this work

Biochemistry

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

Abstract

We have compared allelic polymorphism of two merozoite surface protein genes, MSP-1 and MSP-2, of Plasmodium falciparum and the parasite load in infected individuals in two villages in east Africa. In Michenga village in Tanzania, malaria is holoendemic and transmission is perennial; in Asar village in Sudan, malaria is mesoendemic and transmission is markedly seasonal. The numbers of alleles of both genes were found to be much greater in Michenga than in Asar. More parasite clones exhibiting higher allelic polymorphisms of the genes studied were carried by infected inhabitants in Michenga than those in Asar. The high mean number of clones in Michenga is associated with a very high frequency of out-crossing compared with that estimated in Asar.

Original language	English
Pages (from-to)	141-147
Number of pages	7
Journal	American Journal of Tropical Medicine and Hygiene
Volume	56
Issue number	2
DOIs	https://doi.org/10.4269/ajtmh.1997.56.141
Publication status	Published - 1997

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4269/ajtmh.1997.56.141

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title = "Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa",

abstract = "We have compared allelic polymorphism of two merozoite surface protein genes, MSP-1 and MSP-2, of Plasmodium falciparum and the parasite load in infected individuals in two villages in east Africa. In Michenga village in Tanzania, malaria is holoendemic and transmission is perennial; in Asar village in Sudan, malaria is mesoendemic and transmission is markedly seasonal. The numbers of alleles of both genes were found to be much greater in Michenga than in Asar. More parasite clones exhibiting higher allelic polymorphisms of the genes studied were carried by infected inhabitants in Michenga than those in Asar. The high mean number of clones in Michenga is associated with a very high frequency of out-crossing compared with that estimated in Asar.",

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T1 - Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa

AU - Babiker, Hamza A.

AU - Lines, Jo

AU - Hill, William G.

AU - Walliker, David

PY - 1997

Y1 - 1997

N2 - We have compared allelic polymorphism of two merozoite surface protein genes, MSP-1 and MSP-2, of Plasmodium falciparum and the parasite load in infected individuals in two villages in east Africa. In Michenga village in Tanzania, malaria is holoendemic and transmission is perennial; in Asar village in Sudan, malaria is mesoendemic and transmission is markedly seasonal. The numbers of alleles of both genes were found to be much greater in Michenga than in Asar. More parasite clones exhibiting higher allelic polymorphisms of the genes studied were carried by infected inhabitants in Michenga than those in Asar. The high mean number of clones in Michenga is associated with a very high frequency of out-crossing compared with that estimated in Asar.

AB - We have compared allelic polymorphism of two merozoite surface protein genes, MSP-1 and MSP-2, of Plasmodium falciparum and the parasite load in infected individuals in two villages in east Africa. In Michenga village in Tanzania, malaria is holoendemic and transmission is perennial; in Asar village in Sudan, malaria is mesoendemic and transmission is markedly seasonal. The numbers of alleles of both genes were found to be much greater in Michenga than in Asar. More parasite clones exhibiting higher allelic polymorphisms of the genes studied were carried by infected inhabitants in Michenga than those in Asar. The high mean number of clones in Michenga is associated with a very high frequency of out-crossing compared with that estimated in Asar.

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Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa

Abstract

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