Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa

Hamza A. Babiker, Jo Lines, William G. Hill, David Walliker

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

We have compared allelic polymorphism of two merozoite surface protein genes, MSP-1 and MSP-2, of Plasmodium falciparum and the parasite load in infected individuals in two villages in east Africa. In Michenga village in Tanzania, malaria is holoendemic and transmission is perennial; in Asar village in Sudan, malaria is mesoendemic and transmission is markedly seasonal. The numbers of alleles of both genes were found to be much greater in Michenga than in Asar. More parasite clones exhibiting higher allelic polymorphisms of the genes studied were carried by infected inhabitants in Michenga than those in Asar. The high mean number of clones in Michenga is associated with a very high frequency of out-crossing compared with that estimated in Asar.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume56
Issue number2
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Eastern Africa
Plasmodium falciparum
Malaria
Clone Cells
Merozoite Surface Protein 1
Parasite Load
Population
Genes
Merozoites
Sudan
Tanzania
Membrane Proteins
Parasites
Alleles

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa. / Babiker, Hamza A.; Lines, Jo; Hill, William G.; Walliker, David.

In: American Journal of Tropical Medicine and Hygiene, Vol. 56, No. 2, 1997, p. 141-147.

Research output: Contribution to journalArticle

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