Population dynamics of Plasmodium falciparum in an unstable malaria area of eastern Sudan

H. A. Babiker, A. A. Abdel-Muhsin, A. Hamad, M. J. Mackinnon, W. G. Hill, D. Walliker

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The Plasmodium falciparum population in Asar village, eastern Sudan, where malaria transmission is markedly seasonal, was monitored monthly over a period of 15 months. A cohort of infected patients was treated and then followed monthly throughout the dry season until the next transmission season. Parasitaemia detected by microscopy among the cohort reduced dramatically following treatment, but remained sporadic during the dry season, and reappeared following the onset of the next wet season. However between 40 and 50% of the cohort retained a persisting parasitaemia detectable by PCR throughout the dry season. These parasites were genetically complex, consisting of multiple clones with a large repertoire of alleles of the studied genes. While the number of clones per host dropped significantly following treatment of acute cases during the transmission season, drug treated people nevertheless maintained an average of one clone throughout the dry season. Allele frequencies of MSP-1, MSP-2 and GLURP showed slight, statistically insignificant, fluctuations between the dry and wet seasons. A higher frequency of inbreeding was estimated among the parasites that survived the dry season compared to the wet season.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalParasitology
Volume120
Issue number2
DOIs
Publication statusPublished - 2000

Fingerprint

Sudan
Population Dynamics
Plasmodium falciparum
malaria
Malaria
dry season
population dynamics
wet season
parasitemia
clones
Parasitemia
Clone Cells
parasites
Parasites
inbreeding
gene frequency
Merozoite Surface Protein 1
villages
microscopy
Inbreeding

Keywords

  • Dynamics
  • Malaria
  • Plasmodium falciparum
  • Sudan

ASJC Scopus subject areas

  • Parasitology
  • Immunology

Cite this

Babiker, H. A., Abdel-Muhsin, A. A., Hamad, A., Mackinnon, M. J., Hill, W. G., & Walliker, D. (2000). Population dynamics of Plasmodium falciparum in an unstable malaria area of eastern Sudan. Parasitology, 120(2), 105-111. https://doi.org/10.1017/S0031182099005387

Population dynamics of Plasmodium falciparum in an unstable malaria area of eastern Sudan. / Babiker, H. A.; Abdel-Muhsin, A. A.; Hamad, A.; Mackinnon, M. J.; Hill, W. G.; Walliker, D.

In: Parasitology, Vol. 120, No. 2, 2000, p. 105-111.

Research output: Contribution to journalArticle

Babiker, HA, Abdel-Muhsin, AA, Hamad, A, Mackinnon, MJ, Hill, WG & Walliker, D 2000, 'Population dynamics of Plasmodium falciparum in an unstable malaria area of eastern Sudan', Parasitology, vol. 120, no. 2, pp. 105-111. https://doi.org/10.1017/S0031182099005387
Babiker, H. A. ; Abdel-Muhsin, A. A. ; Hamad, A. ; Mackinnon, M. J. ; Hill, W. G. ; Walliker, D. / Population dynamics of Plasmodium falciparum in an unstable malaria area of eastern Sudan. In: Parasitology. 2000 ; Vol. 120, No. 2. pp. 105-111.
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