Polyphenols and Huntington's disease

T. Manivasagam, A. Justin Thenmozhi, M. Dhivya Bharathi, T. Sumathi, C. Saravanababu, A. Borah, Mohamed Musthafa Essa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Huntington's disease is the most common neurodegenerative disease, characterized by notable cognitive impairment and specific movement disorder. Currently used medications offer symptomatic relief to HD, without preventing the disease progression. Various pre-clinical experiments and clinical trials have shown that the multi-target ability of the traditional herbal medicine and its phytochemicals could offer therapeutic ailment for HD. Plant derived polyphenols are the ubiquitous compound with multiple pharmacological activities including antioxidant, anti-inflammatory, mitochondrial protective and anti-apoptotic activities. They can improve cognitive functions and prevent/delay the onset of certain neurodegenerative disease including HD.

Original languageEnglish
Title of host publicationFood for Huntington's Disease
PublisherNova Science Publishers, Inc.
Pages39-62
Number of pages24
ISBN (Electronic)9781536138559
ISBN (Print)9781536138542
Publication statusPublished - Apr 16 2018

Keywords

  • Huntington's disease
  • Mitochondrial dysfunction
  • Neuroprotection
  • Oxidative stress
  • Polyphenol

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

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  • Cite this

    Manivasagam, T., Justin Thenmozhi, A., Dhivya Bharathi, M., Sumathi, T., Saravanababu, C., Borah, A., & Essa, M. M. (2018). Polyphenols and Huntington's disease. In Food for Huntington's Disease (pp. 39-62). Nova Science Publishers, Inc..