Polyphenols and Huntington's disease

T. Manivasagam, A. Justin Thenmozhi, M. Dhivya Bharathi, T. Sumathi, C. Saravanababu, A. Borah, Mohamed Musthafa Essa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Huntington's disease is the most common neurodegenerative disease, characterized by notable cognitive impairment and specific movement disorder. Currently used medications offer symptomatic relief to HD, without preventing the disease progression. Various pre-clinical experiments and clinical trials have shown that the multi-target ability of the traditional herbal medicine and its phytochemicals could offer therapeutic ailment for HD. Plant derived polyphenols are the ubiquitous compound with multiple pharmacological activities including antioxidant, anti-inflammatory, mitochondrial protective and anti-apoptotic activities. They can improve cognitive functions and prevent/delay the onset of certain neurodegenerative disease including HD.

Original languageEnglish
Title of host publicationFood for Huntington's Disease
PublisherNova Science Publishers, Inc.
Pages39-62
Number of pages24
ISBN (Electronic)9781536138559
ISBN (Print)9781536138542
Publication statusPublished - Apr 16 2018

Fingerprint

Huntington Disease
Polyphenols
Neurodegenerative Diseases
Aptitude
Herbal Medicine
Movement Disorders
Phytochemicals
Traditional Medicine
Cognition
Disease Progression
Anti-Inflammatory Agents
Antioxidants
Clinical Trials
Pharmacology
Therapeutics
Cognitive Dysfunction

Keywords

  • Huntington's disease
  • Mitochondrial dysfunction
  • Neuroprotection
  • Oxidative stress
  • Polyphenol

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

Cite this

Manivasagam, T., Justin Thenmozhi, A., Dhivya Bharathi, M., Sumathi, T., Saravanababu, C., Borah, A., & Essa, M. M. (2018). Polyphenols and Huntington's disease. In Food for Huntington's Disease (pp. 39-62). Nova Science Publishers, Inc..

Polyphenols and Huntington's disease. / Manivasagam, T.; Justin Thenmozhi, A.; Dhivya Bharathi, M.; Sumathi, T.; Saravanababu, C.; Borah, A.; Essa, Mohamed Musthafa.

Food for Huntington's Disease. Nova Science Publishers, Inc., 2018. p. 39-62.

Research output: Chapter in Book/Report/Conference proceedingChapter

Manivasagam, T, Justin Thenmozhi, A, Dhivya Bharathi, M, Sumathi, T, Saravanababu, C, Borah, A & Essa, MM 2018, Polyphenols and Huntington's disease. in Food for Huntington's Disease. Nova Science Publishers, Inc., pp. 39-62.
Manivasagam T, Justin Thenmozhi A, Dhivya Bharathi M, Sumathi T, Saravanababu C, Borah A et al. Polyphenols and Huntington's disease. In Food for Huntington's Disease. Nova Science Publishers, Inc. 2018. p. 39-62
Manivasagam, T. ; Justin Thenmozhi, A. ; Dhivya Bharathi, M. ; Sumathi, T. ; Saravanababu, C. ; Borah, A. ; Essa, Mohamed Musthafa. / Polyphenols and Huntington's disease. Food for Huntington's Disease. Nova Science Publishers, Inc., 2018. pp. 39-62
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