Plasma pharmacokinetics of intravenous and intramuscular furosemide in the camel (Camelus dromedarius)

B. H. Ali, Y. C. Wong, G. A. Alhadrami, B. G. Charles, A. K. Bashir

Research output: Contribution to journalArticle

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Abstract

Single bolus intravenous (i.v.) and intramuscular (i.m.) doses of furosemide (1.5 mg kg-1) were administered in a crossover design to three female and three male adult, dromedary camels. Plasma furosemide concentrations were assayed by HPLC and sodium, potassium and chloride concentrations were measured using ion-selective electrodes. Plasma furosemide concentration time plots: indicated multi-compartment disposition, and there was considerable intersubject variability in the pharmacokinetic parameters. The mean (SD) i.v. terminal elimination half-life was 118 (67) minutes. The systemic clearance was 5.4 (1.2) ml min-1 kg-1, and the steady-state volume of distribution was 0.43 (0.14) litre kg-1. The mean absorption time after i.m. dosing was 33 (62) minutes, while the absolute bioavailability was 71 (20) per cent. The glucuronide metabolite of furosemide was not detected in plasma. Clearance was lower, volume of distribution was larger, and half-life was longer compared with published data for dogs, horses, rats and humans. Plasma potassium and sodium concentrations were significantly diminished (P <0.05) by an average of 35.6 per cent (two to six hours post-dose) and 11.3 per cent (eight hours post-dose), respectively. Plasma chloride concentrations were not significantly affected by furosemide administration.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalResearch in Veterinary Science
Volume64
Issue number1
DOIs
Publication statusPublished - Jan 1998

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furosemide
Camelus
Camelus dromedarius
Furosemide
pharmacokinetics
Pharmacokinetics
half life
Half-Life
specific ion electrodes
dosage
potassium
Ion-Selective Electrodes
Potassium Chloride
Sodium Chloride
sodium chloride
Cross-Over Studies
Biological Availability
Horses
bioavailability
Chlorides

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Plasma pharmacokinetics of intravenous and intramuscular furosemide in the camel (Camelus dromedarius). / Ali, B. H.; Wong, Y. C.; Alhadrami, G. A.; Charles, B. G.; Bashir, A. K.

In: Research in Veterinary Science, Vol. 64, No. 1, 01.1998, p. 69-72.

Research output: Contribution to journalArticle

Ali, B. H. ; Wong, Y. C. ; Alhadrami, G. A. ; Charles, B. G. ; Bashir, A. K. / Plasma pharmacokinetics of intravenous and intramuscular furosemide in the camel (Camelus dromedarius). In: Research in Veterinary Science. 1998 ; Vol. 64, No. 1. pp. 69-72.
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