Phosphaturic mesenchymal tumour in the temporal bone - A rare presentation

Gaurav Ashish, John Mathew, Nihal Thomas, Nitin Kapoor, S. Elanthenral

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Tumour-induced osteomalacia (TIO) is a rare clinical entity in which secondary osteomalacia is induced by tumour-related products. There is impaired reabsorption of phosphorus in the renal tubules and hypophosphatemia as a result of over expression of FGF-23 mRNA. Treatment of choice is considered to be total or near total resection of the tumour. Methods and results: A 49-year-old man had experienced systemic bone pain and bilateral limb weakness for several months. He had refractory hypophosphatemia and marked elevation of serum FGF-23 level. Magnetic resonance imaging (MRI) of the lumbar spine showed a focal lesion in the left temporal bone which was hyper metabolic on positron emission tomography (PET) scan, leading to a diagnosis of TIO. He underwent lateral skull-base surgery after thorough evaluation of the tumour. After the en bloc resection, FGF-23 became gradually undetectable, phosphate reabsorption normalised, and all symptoms were resolved. Conclusions: We present the clinical features and treatment options for this most unusual manifestation of phosphaturic mesenchymal tumour in the temporal bone.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalEgyptian Journal of Ear, Nose, Throat and Allied Sciences
Volume15
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Temporal Bone
Hypophosphatemia
Neoplasms
Skull Base
Positron-Emission Tomography
Phosphorus
Spine
Extremities
Phosphates
Magnetic Resonance Imaging
Kidney
Bone and Bones
Pain
Messenger RNA
Therapeutics
Serum
Oncogenic osteomalacia

Keywords

  • FGF-23
  • Lateral skull base surgery
  • Temporal bone
  • TIO

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Phosphaturic mesenchymal tumour in the temporal bone - A rare presentation. / Ashish, Gaurav; Mathew, John; Thomas, Nihal; Kapoor, Nitin; Elanthenral, S.

In: Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Vol. 15, No. 2, 2014, p. 149-153.

Research output: Contribution to journalArticle

Ashish, Gaurav ; Mathew, John ; Thomas, Nihal ; Kapoor, Nitin ; Elanthenral, S. / Phosphaturic mesenchymal tumour in the temporal bone - A rare presentation. In: Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2014 ; Vol. 15, No. 2. pp. 149-153.
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