Phoenix dactylifera L. Fruits Date Fruit Ameliorate Oxidative Stress in 3-NP Intoxicated PC12 Cells

Musthafa Essa*, Vandita Singh, Nejib Guizani, Tamilarasan Manivasagam, Arokiasamy J. Thenmozhi, Abid Bhat, Bipul Ray, Saravana B. Chidambaram

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Introduction: Date palm fruits (DFs) are reported to possess antimutagenic, antiviral, antifungal, and anti-inflammatory properties. Effect of date fruits in the management of Huntington's is yet to be studied. Methods: The protective effects of DF were measured in terms of superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and reduced glutathione (rGSH), malondialdehyde (MDA) and nitrate/nitrite (NO2/NO3) content in cells. Cellular adenosine triphosphate (ATP) content was also measured. Cytotoxicity assay revealed that DF has the ability to protected cellular viability against 3-NP intoxication. Results: DFs increased the SOD and GPx activities and rGSH content. On the other hand, DF decreased MDA and NO2/NO3 levels in 3-NP intoxicated cells. Interestingly, DF increased ATP content in pheochromocytoma (PC) cells. Conclusion: DF has the ability to encounter 3-NP intoxication induced biochemical changes and improves cellular ATP contents, hence may be an interestingly candidate for further investigations.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalInternational Journal of Nutrition, Pharmacology, Neurological Diseases
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • 3-Nitropropionic acid
  • date fruits
  • disease
  • Huntington's
  • PC12 cells

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Clinical Neurology
  • Pharmacology (medical)

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