Pharmacological modulation of platelet function in hypertension

Andrew D. Blann, Sunil Nadar, Gregory Y H Lip

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

Platelets exert a considerable influence on human morbidity and mortality. The rationale for their study in hypertension follows the observation that the major consequences of hypertension are stroke and myocardial infarction. However, the etiology of these consequences in hypertension is, paradoxically, not hemorrhagic (as might be expected from the effects of high blood pressure), but occlusive, with thrombus being the culprit lesion. Mechanisms of platelet activation include high shear force, activation of the renin-angiotensin system, endothelial changes, and the presence of comorbidity, such as atrial fibrillation. The treatment of high blood pressure brings about a reversal of the changes seen in the cell. This could be in part due to the direct effect of the drug on the megakaryocyte and/or the platelets themselves, or it might simply be due to the reduction in blood pressure. Some drugs, such as calcium channel antagonists and angiotensin II receptor blockers, however, might have direct effects on platelet biochemistry other than reducing blood pressure. Finally, antiplatelet drugs are becoming an important part of the management of high-risk hypertensives, which aim to minimize vascular complications.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalHypertension
Volume42
Issue number1
DOIs
Publication statusPublished - Jul 1 2003

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Blood Platelets
Pharmacology
Hypertension
Blood Pressure
Megakaryocytes
Angiotensin Receptor Antagonists
Platelet Aggregation Inhibitors
Platelet Activation
Risk Management
Calcium Channel Blockers
Renin-Angiotensin System
Pharmaceutical Preparations
Biochemistry
Atrial Fibrillation
Blood Vessels
Comorbidity
Thrombosis
Stroke
Myocardial Infarction
Morbidity

Keywords

  • Antihypertensive therapy
  • Chronic
  • Hypertension
  • Platelet activation

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Pharmacological modulation of platelet function in hypertension. / Blann, Andrew D.; Nadar, Sunil; Lip, Gregory Y H.

In: Hypertension, Vol. 42, No. 1, 01.07.2003, p. 1-7.

Research output: Contribution to journalReview article

Blann, Andrew D. ; Nadar, Sunil ; Lip, Gregory Y H. / Pharmacological modulation of platelet function in hypertension. In: Hypertension. 2003 ; Vol. 42, No. 1. pp. 1-7.
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