Pharmacological benefits of active components of natural products against traumatic brain injury - A review

Selvaraju Subash, Musthafa M. Essa, Samir Al-Adawi, Mushtaq A. Memon, Thamilarasan Manivasagam, Arokiasamy J. Thenmozhi, Mohammed Akbar, Byoung Joon Song, Gilles J. Guillemin

Research output: Contribution to journalReview article

Abstract

Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly growing number of natural compounds with neuro-protective effects have been described. Many efforts have been made to explore the mechanisms for the neuro-protective properties of natural compounds. This review focuses on the beneficial effects of natural products in treating traumatic brain injury (TBI). Numerous epidemiological studies have shown consistent health benefits through the consumption of fruits, vegetables and nuts. In this review, we have summarized the protective effects of natural compounds [apocynin, (-)-epigallocatechin Gallate (EGCG), baicalein, caffeic acid, caffeic acid phenethyl ester, hydroxysaffloryellow A, osthole, oxy-resveratrol, pycnogenol, resveratrol, salvianolicacid B, triptolide and wogonin], and omega-3 fatty acid, particularly docosahexaenoic acid and its metabolites, may be used as personalized medicine against TBI and we have also discussed some of the barricades in translating these biofunctional compounds into relevant therapeutics for TBI. Conclusion: The benefits of natural products for traumatic brain injury show high inter-individual variability in their therapeutic effects and thus, this article addresses the intersection between novel therapeutics for traumatic brain injury and personalized medicine that will allow a broader range of interventions including the evidence-based natural products.

Original languageEnglish
Pages (from-to)99-116
Number of pages18
JournalCurrent Pharmacogenomics and Personalized Medicine
Volume13
Issue number2
Publication statusPublished - Aug 1 2015

Fingerprint

Biological Products
Pharmacology
Precision Medicine
Nuts
Docosahexaenoic Acids
Omega-3 Fatty Acids
Therapeutic Uses
Insurance Benefits
Vegetables
Epidemiologic Studies
Fruit
Therapeutics
Antioxidants
Traumatic Brain Injury
resveratrol

Keywords

  • EGCG
  • Natural products
  • Oxidative stress
  • Phytochemicals
  • Resveratrol
  • Traumatic brain injury

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Pharmacology
  • Molecular Biology
  • Genetics(clinical)

Cite this

Pharmacological benefits of active components of natural products against traumatic brain injury - A review. / Subash, Selvaraju; Essa, Musthafa M.; Al-Adawi, Samir; Memon, Mushtaq A.; Manivasagam, Thamilarasan; Thenmozhi, Arokiasamy J.; Akbar, Mohammed; Song, Byoung Joon; Guillemin, Gilles J.

In: Current Pharmacogenomics and Personalized Medicine, Vol. 13, No. 2, 01.08.2015, p. 99-116.

Research output: Contribution to journalReview article

Subash, S, Essa, MM, Al-Adawi, S, Memon, MA, Manivasagam, T, Thenmozhi, AJ, Akbar, M, Song, BJ & Guillemin, GJ 2015, 'Pharmacological benefits of active components of natural products against traumatic brain injury - A review', Current Pharmacogenomics and Personalized Medicine, vol. 13, no. 2, pp. 99-116.
Subash, Selvaraju ; Essa, Musthafa M. ; Al-Adawi, Samir ; Memon, Mushtaq A. ; Manivasagam, Thamilarasan ; Thenmozhi, Arokiasamy J. ; Akbar, Mohammed ; Song, Byoung Joon ; Guillemin, Gilles J. / Pharmacological benefits of active components of natural products against traumatic brain injury - A review. In: Current Pharmacogenomics and Personalized Medicine. 2015 ; Vol. 13, No. 2. pp. 99-116.
@article{156e34b0a5834d0195a5f180690af601,
title = "Pharmacological benefits of active components of natural products against traumatic brain injury - A review",
abstract = "Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly growing number of natural compounds with neuro-protective effects have been described. Many efforts have been made to explore the mechanisms for the neuro-protective properties of natural compounds. This review focuses on the beneficial effects of natural products in treating traumatic brain injury (TBI). Numerous epidemiological studies have shown consistent health benefits through the consumption of fruits, vegetables and nuts. In this review, we have summarized the protective effects of natural compounds [apocynin, (-)-epigallocatechin Gallate (EGCG), baicalein, caffeic acid, caffeic acid phenethyl ester, hydroxysaffloryellow A, osthole, oxy-resveratrol, pycnogenol, resveratrol, salvianolicacid B, triptolide and wogonin], and omega-3 fatty acid, particularly docosahexaenoic acid and its metabolites, may be used as personalized medicine against TBI and we have also discussed some of the barricades in translating these biofunctional compounds into relevant therapeutics for TBI. Conclusion: The benefits of natural products for traumatic brain injury show high inter-individual variability in their therapeutic effects and thus, this article addresses the intersection between novel therapeutics for traumatic brain injury and personalized medicine that will allow a broader range of interventions including the evidence-based natural products.",
keywords = "EGCG, Natural products, Oxidative stress, Phytochemicals, Resveratrol, Traumatic brain injury",
author = "Selvaraju Subash and Essa, {Musthafa M.} and Samir Al-Adawi and Memon, {Mushtaq A.} and Thamilarasan Manivasagam and Thenmozhi, {Arokiasamy J.} and Mohammed Akbar and Song, {Byoung Joon} and Guillemin, {Gilles J.}",
year = "2015",
month = "8",
day = "1",
language = "English",
volume = "13",
pages = "99--116",
journal = "Current Pharmacogenomics and Personalized Medicine",
issn = "1875-6921",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Pharmacological benefits of active components of natural products against traumatic brain injury - A review

AU - Subash, Selvaraju

AU - Essa, Musthafa M.

AU - Al-Adawi, Samir

AU - Memon, Mushtaq A.

AU - Manivasagam, Thamilarasan

AU - Thenmozhi, Arokiasamy J.

AU - Akbar, Mohammed

AU - Song, Byoung Joon

AU - Guillemin, Gilles J.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly growing number of natural compounds with neuro-protective effects have been described. Many efforts have been made to explore the mechanisms for the neuro-protective properties of natural compounds. This review focuses on the beneficial effects of natural products in treating traumatic brain injury (TBI). Numerous epidemiological studies have shown consistent health benefits through the consumption of fruits, vegetables and nuts. In this review, we have summarized the protective effects of natural compounds [apocynin, (-)-epigallocatechin Gallate (EGCG), baicalein, caffeic acid, caffeic acid phenethyl ester, hydroxysaffloryellow A, osthole, oxy-resveratrol, pycnogenol, resveratrol, salvianolicacid B, triptolide and wogonin], and omega-3 fatty acid, particularly docosahexaenoic acid and its metabolites, may be used as personalized medicine against TBI and we have also discussed some of the barricades in translating these biofunctional compounds into relevant therapeutics for TBI. Conclusion: The benefits of natural products for traumatic brain injury show high inter-individual variability in their therapeutic effects and thus, this article addresses the intersection between novel therapeutics for traumatic brain injury and personalized medicine that will allow a broader range of interventions including the evidence-based natural products.

AB - Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly growing number of natural compounds with neuro-protective effects have been described. Many efforts have been made to explore the mechanisms for the neuro-protective properties of natural compounds. This review focuses on the beneficial effects of natural products in treating traumatic brain injury (TBI). Numerous epidemiological studies have shown consistent health benefits through the consumption of fruits, vegetables and nuts. In this review, we have summarized the protective effects of natural compounds [apocynin, (-)-epigallocatechin Gallate (EGCG), baicalein, caffeic acid, caffeic acid phenethyl ester, hydroxysaffloryellow A, osthole, oxy-resveratrol, pycnogenol, resveratrol, salvianolicacid B, triptolide and wogonin], and omega-3 fatty acid, particularly docosahexaenoic acid and its metabolites, may be used as personalized medicine against TBI and we have also discussed some of the barricades in translating these biofunctional compounds into relevant therapeutics for TBI. Conclusion: The benefits of natural products for traumatic brain injury show high inter-individual variability in their therapeutic effects and thus, this article addresses the intersection between novel therapeutics for traumatic brain injury and personalized medicine that will allow a broader range of interventions including the evidence-based natural products.

KW - EGCG

KW - Natural products

KW - Oxidative stress

KW - Phytochemicals

KW - Resveratrol

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=84974676490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974676490&partnerID=8YFLogxK

M3 - Review article

VL - 13

SP - 99

EP - 116

JO - Current Pharmacogenomics and Personalized Medicine

JF - Current Pharmacogenomics and Personalized Medicine

SN - 1875-6921

IS - 2

ER -