Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals

M. O M Tanira, A. H. Shah, A. Mohsin, A. M. Ageel, S. Qureshi

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The ethanol extract of the dried ripe fruit of Foeniculum vulgare (500 mg/kg) was tested for diuretic, analgesic, antipyretic, antimicrobial, cytotoxic activities and its effect on bile secretion in rats. Also, the acute toxicity after 0.5, 1 and 3 g/kg was investigated in mice. The extract showed diuretic, analgesic, antipyretic activities and it enhanced bile secretion. As an antimicrobial agent, the extract inhibited the growth of Staphylococcus aureus and Bacillus subtilis and showed a marked mitodepressive effect. At a dose of 3 g/kg, it caused piloerection and it depressed locomotor activity but caused no deaths when administered acutely to mice.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalPhytotherapy Research
Volume10
Issue number1
DOIs
Publication statusPublished - Feb 1996

Keywords

  • Analgesic
  • Antimicrobial
  • Antipyretic
  • Bile flow
  • Diuretic
  • Foeniculum vulgare
  • Mitotic index

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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