Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals

M. O.M. Tanira; A. H. Shah; A. Mohsin; A. M. Ageel; S. Qureshi

doi:10.1002/(SICI)1099-1573(199602)10:1<33::AID-PTR769>3.0.CO;2-L

Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals

M. O.M. Tanira^*, A. H. Shah, A. Mohsin, A. M. Ageel, S. Qureshi

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

The ethanol extract of the dried ripe fruit of Foeniculum vulgare (500 mg/kg) was tested for diuretic, analgesic, antipyretic, antimicrobial, cytotoxic activities and its effect on bile secretion in rats. Also, the acute toxicity after 0.5, 1 and 3 g/kg was investigated in mice. The extract showed diuretic, analgesic, antipyretic activities and it enhanced bile secretion. As an antimicrobial agent, the extract inhibited the growth of Staphylococcus aureus and Bacillus subtilis and showed a marked mitodepressive effect. At a dose of 3 g/kg, it caused piloerection and it depressed locomotor activity but caused no deaths when administered acutely to mice.

Original language	English
Pages (from-to)	33-36
Number of pages	4
Journal	Phytotherapy Research
Volume	10
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1099-1573(199602)10:1<33::AID-PTR769>3.0.CO;2-L
Publication status	Published - Feb 1996

Keywords

Analgesic
Antimicrobial
Antipyretic
Bile flow
Diuretic
Foeniculum vulgare
Mitotic index

ASJC Scopus subject areas

Pharmacology

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10.1002/(SICI)1099-1573(199602)10:1<33::AID-PTR769>3.0.CO;2-L

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title = "Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals",

abstract = "The ethanol extract of the dried ripe fruit of Foeniculum vulgare (500 mg/kg) was tested for diuretic, analgesic, antipyretic, antimicrobial, cytotoxic activities and its effect on bile secretion in rats. Also, the acute toxicity after 0.5, 1 and 3 g/kg was investigated in mice. The extract showed diuretic, analgesic, antipyretic activities and it enhanced bile secretion. As an antimicrobial agent, the extract inhibited the growth of Staphylococcus aureus and Bacillus subtilis and showed a marked mitodepressive effect. At a dose of 3 g/kg, it caused piloerection and it depressed locomotor activity but caused no deaths when administered acutely to mice.",

keywords = "Analgesic, Antimicrobial, Antipyretic, Bile flow, Diuretic, Foeniculum vulgare, Mitotic index",

author = "Tanira, {M. O.M.} and Shah, {A. H.} and A. Mohsin and Ageel, {A. M.} and S. Qureshi",

year = "1996",

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AU - Shah, A. H.

AU - Mohsin, A.

AU - Ageel, A. M.

AU - Qureshi, S.

PY - 1996/2

Y1 - 1996/2

N2 - The ethanol extract of the dried ripe fruit of Foeniculum vulgare (500 mg/kg) was tested for diuretic, analgesic, antipyretic, antimicrobial, cytotoxic activities and its effect on bile secretion in rats. Also, the acute toxicity after 0.5, 1 and 3 g/kg was investigated in mice. The extract showed diuretic, analgesic, antipyretic activities and it enhanced bile secretion. As an antimicrobial agent, the extract inhibited the growth of Staphylococcus aureus and Bacillus subtilis and showed a marked mitodepressive effect. At a dose of 3 g/kg, it caused piloerection and it depressed locomotor activity but caused no deaths when administered acutely to mice.

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KW - Antipyretic

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KW - Diuretic

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KW - Mitotic index

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Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals

Abstract

Keywords

ASJC Scopus subject areas

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