Pharmacokinetics of topical clonidine

Ramanjit Sihota, Anuradha Ganesh, Gurupad Bandopadhyaya, Narendra Nath Sood, Suresh Kumar Gupta

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The ocular penetration and systemic bioavailability following topical instillation between 0.125% and 0.06% clonidine were studied in rabbit eyes. The clonidine was bound to Tc 99m and assayed with a sensitivity of 0.006 mg/100 ul. In aqueous peak levels of clonidine were measured one hour after instillation, being 0.064 ug/100 ul with 0.125% clonidine and 0.061 ug/100ul with 0.06% clonidine. In the blood half an hour after administration 0.009 ug/100 ul of clonidine was present using 0.125% clonidine and 0.008 ug/100ul with 0.06% clonidine. Both concentrations of clonidine achieve similar aqueous and serum levels, suggesting an almost equal effect on intraocular pressure, with a small and transient effect on blood pressure.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
JournalAnnals of Ophthalmology
Volume27
Issue number1
Publication statusPublished - Jan 1995

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Clonidine
Pharmacokinetics
Intraocular Pressure
Biological Availability
Rabbits
Blood Pressure
Serum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Sihota, R., Ganesh, A., Bandopadhyaya, G., Sood, N. N., & Gupta, S. K. (1995). Pharmacokinetics of topical clonidine. Annals of Ophthalmology, 27(1), 4-8.

Pharmacokinetics of topical clonidine. / Sihota, Ramanjit; Ganesh, Anuradha; Bandopadhyaya, Gurupad; Sood, Narendra Nath; Gupta, Suresh Kumar.

In: Annals of Ophthalmology, Vol. 27, No. 1, 01.1995, p. 4-8.

Research output: Contribution to journalArticle

Sihota, R, Ganesh, A, Bandopadhyaya, G, Sood, NN & Gupta, SK 1995, 'Pharmacokinetics of topical clonidine', Annals of Ophthalmology, vol. 27, no. 1, pp. 4-8.
Sihota R, Ganesh A, Bandopadhyaya G, Sood NN, Gupta SK. Pharmacokinetics of topical clonidine. Annals of Ophthalmology. 1995 Jan;27(1):4-8.
Sihota, Ramanjit ; Ganesh, Anuradha ; Bandopadhyaya, Gurupad ; Sood, Narendra Nath ; Gupta, Suresh Kumar. / Pharmacokinetics of topical clonidine. In: Annals of Ophthalmology. 1995 ; Vol. 27, No. 1. pp. 4-8.
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