Abstract
The ocular penetration and systemic bioavailability following topical instillation between 0.125% and 0.06% clonidine were studied in rabbit eyes. The clonidine was bound to Tc 99m and assayed with a sensitivity of 0.006 mg/100 ul. In aqueous peak levels of clonidine were measured one hour after instillation, being 0.064 ug/100 ul with 0.125% clonidine and 0.061 ug/100ul with 0.06% clonidine. In the blood half an hour after administration 0.009 ug/100 ul of clonidine was present using 0.125% clonidine and 0.008 ug/100ul with 0.06% clonidine. Both concentrations of clonidine achieve similar aqueous and serum levels, suggesting an almost equal effect on intraocular pressure, with a small and transient effect on blood pressure.
Original language | English |
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Pages (from-to) | 4-8 |
Number of pages | 5 |
Journal | Annals of Ophthalmology |
Volume | 27 |
Issue number | 1 |
Publication status | Published - Jan 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology