Pharmacokinetics of antipyrine and sulphadimidine (sulfamethazine) in camels, sheep and goats

H. A. Elsheikh, B. H. Ali, A. M. Homeida, T. Hassan, H. J. Hapke

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The pharmacokinetics of antipyrine and sulphadimidine were studied in male camels, sheep and goats. The two drugs were administered concomitantly. Following intravenous injection of antipyrine (25 mg/kg) and sulphadimidine (sulfamethazine) (100 mg/kg), the pharmacokinetics of the two drugs were adequately described by a one-compartment model. Antipyrine half-life in goats (2.58 h) was shorter than that in sheep (4.04 h) and camels (18.78 h). The plasma clearance was greatest in goats then sheep and then camels. For sulphadimidine, a significantly greater volume of distribution was observed in camels and the greatest plasma clearance and shortest half-life were reported in goats. Sulphadimidine half-life was 2.77 h in goats, 4.72 h in sheep and 7.36 h in camels. The present results suggest that goats have the fastest elimination of these drugs from the circulation, followed by sheep and then camels.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume14
Issue number3
Publication statusPublished - 1991

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this