Pharmacokinetics of antipyrine and sulphadimidine (sulfamethazine) in camels, sheep and goats

H. A. Elsheikh, B. H. Ali, A. M. Homeida, T. Hassan, H. J. Hapke

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The pharmacokinetics of antipyrine and sulphadimidine were studied in male camels, sheep and goats. The two drugs were administered concomitantly. Following intravenous injection of antipyrine (25 mg/kg) and sulphadimidine (sulfamethazine) (100 mg/kg), the pharmacokinetics of the two drugs were adequately described by a one-compartment model. Antipyrine half-life in goats (2.58 h) was shorter than that in sheep (4.04 h) and camels (18.78 h). The plasma clearance was greatest in goats then sheep and then camels. For sulphadimidine, a significantly greater volume of distribution was observed in camels and the greatest plasma clearance and shortest half-life were reported in goats. Sulphadimidine half-life was 2.77 h in goats, 4.72 h in sheep and 7.36 h in camels. The present results suggest that goats have the fastest elimination of these drugs from the circulation, followed by sheep and then camels.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume14
Issue number3
Publication statusPublished - 1991

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Sulfamethazine
antipyrine
Antipyrine
Camelus
camels
Goats
pharmacokinetics
Sheep
Pharmacokinetics
goats
sheep
half life
Half-Life
drug excretion
Pharmaceutical Preparations
drugs
intravenous injection
Intravenous Injections

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Pharmacokinetics of antipyrine and sulphadimidine (sulfamethazine) in camels, sheep and goats. / Elsheikh, H. A.; Ali, B. H.; Homeida, A. M.; Hassan, T.; Hapke, H. J.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 14, No. 3, 1991, p. 269-275.

Research output: Contribution to journalArticle

Elsheikh, H. A. ; Ali, B. H. ; Homeida, A. M. ; Hassan, T. ; Hapke, H. J. / Pharmacokinetics of antipyrine and sulphadimidine (sulfamethazine) in camels, sheep and goats. In: Journal of Veterinary Pharmacology and Therapeutics. 1991 ; Vol. 14, No. 3. pp. 269-275.
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