Pertussis and pertussis like illness

Pediatric experience in Oman

Amal Al Maani, Abdullah Al Qayoudhi, Hanan Fawzi Nazir, Heba Omar, Amina Al Jardani, Zakariya Al Muharrmi, Yasser Wali

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: A resurgence of pertussis or whooping cough has been observed worldwide despite broad vaccination coverage. Pertussis like illness (PL I) refers to a clinical syndrome compatible with pertussis infection but lacking laboratory confirmation or an epidemiological link to a confirmed case. Our study aimed to estimate the contribution of Bordetella pertussis infection and identifying predictors of its diagnosis in a cohort of children with PL I. Methods: Demographic and clinical information were retrospectively collected from the medical records of children < 13 years old and hospitalized for PL I in two pediatric units in Oman from 1 January 2012 to 31 December 2013. The laboratory data of all cases were reviewed and confirmed cases of pertussis were identified, analyzed, and compared with non-confirmed cases. Results: A total of 131 patients were enrolled in this study. The majority (95.4% [125/131]) were infants. Only 54.1% (71/131) of admitted children with PL I were tested for pertussis. The incidence of pertussis infection among the tested group was 16.9% (12/71) with a 95% confidence interval 8.2−25.6. Severe illness occurred in 56.4% (74/131) of patients, and six were confirmed to have pertussis. Pediatric intensive care unit admission was required for one confirmed case of pertussis and eight cases from the PL I group (three were negative for pertussis, and five were not tested). Receiver operator characteristic curve analysis revealed that a white blood cell count ≥ 23.5 × 109/L had 96.6% specificity and lymphocytes ≥ 17 × 109/L had 98.3% specificity. Conclusions: Taking into consideration that the number tested for pertussis was limited, the incidence of pertussis was 16.9% (12 out of 71 patients). Lymphocytosis can be used as a reliable predictor for the diagnosis of pertussis especially in the absence of specific confirmatory tests or until their results are available.

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalOman Medical Journal
Volume32
Issue number5
DOIs
Publication statusPublished - Sep 1 2017

Fingerprint

Oman
Whooping Cough
Pediatrics
Bordetella Infections
Laboratory Infection
Lymphocytosis
Bordetella pertussis
Pediatric Intensive Care Units

Keywords

  • Children
  • Immunization
  • Infants
  • Oman
  • Pertussis
  • Respiratory
  • Viruses

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pertussis and pertussis like illness : Pediatric experience in Oman. / Al Maani, Amal; Al Qayoudhi, Abdullah; Nazir, Hanan Fawzi; Omar, Heba; Al Jardani, Amina; Al Muharrmi, Zakariya; Wali, Yasser.

In: Oman Medical Journal, Vol. 32, No. 5, 01.09.2017, p. 396-402.

Research output: Contribution to journalArticle

Al Maani, A, Al Qayoudhi, A, Nazir, HF, Omar, H, Al Jardani, A, Al Muharrmi, Z & Wali, Y 2017, 'Pertussis and pertussis like illness: Pediatric experience in Oman', Oman Medical Journal, vol. 32, no. 5, pp. 396-402. https://doi.org/10.5001/omj.2017.75
Al Maani A, Al Qayoudhi A, Nazir HF, Omar H, Al Jardani A, Al Muharrmi Z et al. Pertussis and pertussis like illness: Pediatric experience in Oman. Oman Medical Journal. 2017 Sep 1;32(5):396-402. https://doi.org/10.5001/omj.2017.75
Al Maani, Amal ; Al Qayoudhi, Abdullah ; Nazir, Hanan Fawzi ; Omar, Heba ; Al Jardani, Amina ; Al Muharrmi, Zakariya ; Wali, Yasser. / Pertussis and pertussis like illness : Pediatric experience in Oman. In: Oman Medical Journal. 2017 ; Vol. 32, No. 5. pp. 396-402.
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