TY - JOUR
T1 - Peripheral Demyelinating Diseases
T2 - From Biology to Translational Medicine
AU - Kamil, Khidhir
AU - Yazid, Muhammad Dain
AU - Idrus, Ruszymah Bt Hj
AU - Das, Srijit
AU - Kumar, Jaya
N1 - Publisher Copyright:
© Copyright © 2019 Kamil, Yazid, Idrus, Das and Kumar.
PY - 2019/3/19
Y1 - 2019/3/19
N2 - Demyelinating diseases represent a spectrum of disorders that impose significant burden on global economy and society. Generally, the prognosis of these diseases is poor and there is no available cure. In recent decades, research has shed some light on the biology and physiology of Schwann cells and its neuroprotective effects in the peripheral nervous system (PNS). Insults to the PNS by various infectious agents, genetic predisposition and immune-related mechanisms jeopardize Schwann cell functions and cause demyelination. To date, there are no effective and reliable biomarkers for PNS-related diseases. Here, we aim to review the following: pathogenesis of various types of peripheral demyelinating diseases such as Guillain-Barre syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Anti-Myelin Associated Glycoprotein Neuropathy, POEMS syndrome, and Charcot-Marie-Tooth disease; emerging novel biomarkers for peripheral demyelinating diseases, and Schwann cell associated markers for demyelination.
AB - Demyelinating diseases represent a spectrum of disorders that impose significant burden on global economy and society. Generally, the prognosis of these diseases is poor and there is no available cure. In recent decades, research has shed some light on the biology and physiology of Schwann cells and its neuroprotective effects in the peripheral nervous system (PNS). Insults to the PNS by various infectious agents, genetic predisposition and immune-related mechanisms jeopardize Schwann cell functions and cause demyelination. To date, there are no effective and reliable biomarkers for PNS-related diseases. Here, we aim to review the following: pathogenesis of various types of peripheral demyelinating diseases such as Guillain-Barre syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Anti-Myelin Associated Glycoprotein Neuropathy, POEMS syndrome, and Charcot-Marie-Tooth disease; emerging novel biomarkers for peripheral demyelinating diseases, and Schwann cell associated markers for demyelination.
KW - Charcot-Marie-Tooth disease
KW - Guillain-Barre syndrome
KW - POEMS syndrome
KW - anti-MAG neuropathy
KW - biomarker
KW - chronic inflammatory demyelinating polyradiculoneuropathy
KW - peripheral demyelinating disease
KW - schwann cell
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U2 - 10.3389/fneur.2019.00087
DO - 10.3389/fneur.2019.00087
M3 - Review article
AN - SCOPUS:85078569439
SN - 1664-2295
VL - 10
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 87
ER -