Pediatric hyperfibrotic myelodysplasia: An unusual clinicopathologic entity

Satyajit Sahu, Samir S. Shah, Alok Srivastava, David Dennison, Mammen Chandy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study is presented to highlight a rare pediatric bone marrow pathology in which features of bone marrow dysplasia coexist with severe fibrosis in a clinical setting of fever, anemia, and organomegaly. Fourteen children (nine males, five females) clinically presented with fever, anemia, and hepatosplenomegaly. Extensive bone marrow fibrosis with dysplastic features was seen in their marrow precursor cells. Peripheral blood smears showed teardrop poikilocytes, thrombocytopenia, and occasional blasts. In conclusion, pediatric hyperfibrotic myelodysplasia is a distinct clinicopathologic entity. Myeloproliferative and dysmyelopoietic syndromes are complex disorders that are interrelated and not always easily diagnosed only on morphologic grounds.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalPediatric Hematology and Oncology
Volume14
Issue number2
Publication statusPublished - Mar 1997

Keywords

  • hyperfibrotic
  • myelodysplasia
  • pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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