Pattern of childhood neuronal migrational disorders in Oman

Roshan L. Koul, Amna M. Alfuitasi, Dilip K. Sankhla, Hashim Javad, Ranjan R. William

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: To record the pattern of different neuronal migrational disorders (NMD) and their associated neurological conditions. Methods: The data were collected at the Child Neurology Services of Sultan Qaboos University Hospital, Oman, from January 1993 to September 2006 from all children with psychomotor delay and epilepsy, who underwent brain imaging (mostly MRI). The MR imaging was used for the diagnosis of a neuronal migration anomaly. Results: There were 86 cases of NMD. Corpus callosum agenesis and lissencephaly/ pachygyria formed the major group. There were 48 cases of corpus callosum agenesis, and 16 cases of lissencephaly/ pachygyria. Other disorders were 10 cases of heterotopias, 5 schizencephaly, 3 holoprosencephaly, 2 polymicrogyria, and one each of hemimegalencephaly, and hydranencephaly. Developmental delay was the most common associated finding noted in 80 (93%) cases. Sixty-seven (77.9%) cases had motor deficit. Forty out of 86 (46.5%) cases had epilepsy. Partial/ partial complex seizures were the most common at 13 out of 40 (32.5%). Syndromic seizures were seen in 11 out of 40 (27.5%) cases. The seizures were controlled in only 3/40 (7.5%) cases. Conclusions: The NMD constitute a significant number of child neurology patients with psychomotor delay and intractable epilepsy. Exogenic and genetic factors affecting the early embryonic and fetal development from sixth to twenty-sixth weeks of gestation result in NMD. Recent genetic studies are defining the underlying mechanism and these studies will help in early diagnosis and possible prevention of NMD.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalNeurosciences
Volume14
Issue number2
Publication statusPublished - Apr 2009

Fingerprint

Lissencephaly
Oman
Complex Partial Epilepsy
Seizures
Neurology
Hydranencephaly
Embryonic and Fetal Development
Agenesis of Corpus Callosum
Neuroimaging
Early Diagnosis
Epilepsy
Pregnancy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Koul, R. L., Alfuitasi, A. M., Sankhla, D. K., Javad, H., & William, R. R. (2009). Pattern of childhood neuronal migrational disorders in Oman. Neurosciences, 14(2), 158-162.

Pattern of childhood neuronal migrational disorders in Oman. / Koul, Roshan L.; Alfuitasi, Amna M.; Sankhla, Dilip K.; Javad, Hashim; William, Ranjan R.

In: Neurosciences, Vol. 14, No. 2, 04.2009, p. 158-162.

Research output: Contribution to journalArticle

Koul, RL, Alfuitasi, AM, Sankhla, DK, Javad, H & William, RR 2009, 'Pattern of childhood neuronal migrational disorders in Oman', Neurosciences, vol. 14, no. 2, pp. 158-162.
Koul RL, Alfuitasi AM, Sankhla DK, Javad H, William RR. Pattern of childhood neuronal migrational disorders in Oman. Neurosciences. 2009 Apr;14(2):158-162.
Koul, Roshan L. ; Alfuitasi, Amna M. ; Sankhla, Dilip K. ; Javad, Hashim ; William, Ranjan R. / Pattern of childhood neuronal migrational disorders in Oman. In: Neurosciences. 2009 ; Vol. 14, No. 2. pp. 158-162.
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