Pathology of allergic encephalomyelopathies following Semple type antirabies vaccine from india

A. Kumar, H. S. Swamy, V. Santosh, A. B. Taly, G. R. Arunodaya, S. K. Shankar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Twelve fatal cases of neurological complications following β- propionolactone inactivated antirabies [Semple] vaccine were studied. Neurological deficits consisted of polyradiculopathy in four patients, dorsolumbar myelopathy in two, myeloradiculopathy in two and encephalomyeloradiculopathy in four. Pathological findings revealed the same degree of involvement of both the central and peripheral nervous systems. White matter was more involved than grey matter, in the form of perivenous demyelination. The features resembled those of acute necrotizing haemorrhagic leucoencephalitis. Two cases had perivenous demyelinating lesions in the cortex, along with rabies encephalitis. The pathological lesions were far more extensive than those detected by clinical localization.

Original languageEnglish
Pages (from-to)239-248
Number of pages10
JournalNeurological Infections and Epidemology
Issue number4
Publication statusPublished - 1997
Externally publishedYes


  • Acute disseminated encephalomyelitis
  • Necrotizing myelitis
  • Perivenous demyelination
  • Semple antirabies vaccine

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Clinical Neurology


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