Papaya epicarp extract protects against hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuronal cells

Nejib Guizani; Mostafa I. Waly; Amanat Ali; Ghalib Al-Saidi; Vendita Singh; Neeru Bhatt; Mohammad Shafiur Rahman

doi:10.1258/ebm.2011.011031

Papaya epicarp extract protects against hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuronal cells

Nejib Guizani, Mostafa I. Waly, Amanat Ali, Ghalib Al-Saidi, Vendita Singh, Neeru Bhatt, Mohammad Shafiur Rahman

Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Recent studies indicated that regular consumption of antioxidant-rich foods reduces cellular oxidative stress and protects against health-related problems. This study aimed to assess the in vitro antioxidant properties of the papaya epicarp extract against hydrogen peroxide (H ₂O ₂)-induced oxidative stress in human SH-SY5Y neuronal cells. Our study revealed that papaya epicarp extract acted as a potent free radical scavenger and provided neuroprotection against H ₂O ₂-induced oxidative stress. Papaya epicarp extract ameliorated glutathione depletion, restored total antioxidant capacity and augmented the inhibition of antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). In conclusion, papaya epicarp extract can be used as a functional dietary ingredient that might help in reducing the neurological health problems associated with various oxidative stress insults.

Original language	English
Pages (from-to)	1205-1210
Number of pages	6
Journal	Experimental Biology and Medicine
Volume	236
Issue number	10
DOIs	https://doi.org/10.1258/ebm.2011.011031
Publication status	Published - Oct 2011

Keywords

Antioxidant enzymes
Glutathione
Oxidative stress
Total antioxidant capacity

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1258/ebm.2011.011031

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title = "Papaya epicarp extract protects against hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuronal cells",

abstract = "Recent studies indicated that regular consumption of antioxidant-rich foods reduces cellular oxidative stress and protects against health-related problems. This study aimed to assess the in vitro antioxidant properties of the papaya epicarp extract against hydrogen peroxide (H 2O 2)-induced oxidative stress in human SH-SY5Y neuronal cells. Our study revealed that papaya epicarp extract acted as a potent free radical scavenger and provided neuroprotection against H 2O 2-induced oxidative stress. Papaya epicarp extract ameliorated glutathione depletion, restored total antioxidant capacity and augmented the inhibition of antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). In conclusion, papaya epicarp extract can be used as a functional dietary ingredient that might help in reducing the neurological health problems associated with various oxidative stress insults.",

keywords = "Antioxidant enzymes, Glutathione, Oxidative stress, Total antioxidant capacity",

author = "Nejib Guizani and Waly, {Mostafa I.} and Amanat Ali and Ghalib Al-Saidi and Vendita Singh and Neeru Bhatt and Rahman, {Mohammad Shafiur}",

note = "Funding Information: This study was supported by Sultan Qaboos University research funds, IG/AGR/FOOD/10/01 and IG/AGR/FOOD/10/02, and by the International Islamic University Malaysia Grant, IIUM/504/RES/G/14/3/RMGS/08-04.",

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AU - Guizani, Nejib

AU - Waly, Mostafa I.

AU - Ali, Amanat

AU - Al-Saidi, Ghalib

AU - Singh, Vendita

AU - Bhatt, Neeru

AU - Rahman, Mohammad Shafiur

N1 - Funding Information: This study was supported by Sultan Qaboos University research funds, IG/AGR/FOOD/10/01 and IG/AGR/FOOD/10/02, and by the International Islamic University Malaysia Grant, IIUM/504/RES/G/14/3/RMGS/08-04.

PY - 2011/10

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N2 - Recent studies indicated that regular consumption of antioxidant-rich foods reduces cellular oxidative stress and protects against health-related problems. This study aimed to assess the in vitro antioxidant properties of the papaya epicarp extract against hydrogen peroxide (H 2O 2)-induced oxidative stress in human SH-SY5Y neuronal cells. Our study revealed that papaya epicarp extract acted as a potent free radical scavenger and provided neuroprotection against H 2O 2-induced oxidative stress. Papaya epicarp extract ameliorated glutathione depletion, restored total antioxidant capacity and augmented the inhibition of antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). In conclusion, papaya epicarp extract can be used as a functional dietary ingredient that might help in reducing the neurological health problems associated with various oxidative stress insults.

AB - Recent studies indicated that regular consumption of antioxidant-rich foods reduces cellular oxidative stress and protects against health-related problems. This study aimed to assess the in vitro antioxidant properties of the papaya epicarp extract against hydrogen peroxide (H 2O 2)-induced oxidative stress in human SH-SY5Y neuronal cells. Our study revealed that papaya epicarp extract acted as a potent free radical scavenger and provided neuroprotection against H 2O 2-induced oxidative stress. Papaya epicarp extract ameliorated glutathione depletion, restored total antioxidant capacity and augmented the inhibition of antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). In conclusion, papaya epicarp extract can be used as a functional dietary ingredient that might help in reducing the neurological health problems associated with various oxidative stress insults.

KW - Antioxidant enzymes

KW - Glutathione

KW - Oxidative stress

KW - Total antioxidant capacity

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Papaya epicarp extract protects against hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuronal cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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