Oxidation-responsive polymeric vesicles

Alessandro Napoli, Massimiliano Valentini, Nicola Tirelli, Martin Müller, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

560 Citations (Scopus)

Abstract

Vesicles formed in water by synthetic macro-amphiphiles have attracted much attention as nanocontainers having properties that extend the physical and chemical limits of liposomes. We sought to develop ABA block copolymeric amphiphiles that self-assemble into unilamellar vesicles that can be further oxidatively destabilized. We selected poly(ethylene glycol) (PEG) as the hydrophilic A blocks, owing to its resistance to protein adsorption and low toxicity. As hydrophobic B blocks, we selected poly(propylene sulphide) (PPS), owing to its extreme hydrophobicity, its low glass-transition temperature, and most importantly its oxidative conversion from a hydrophobe to a hydrophile, poly(propylene sulphoxide) and ultimately poly(propylene sulphone). This is the first example of the use of oxidative conversions to destabilize such carriers. This new class of oxidation-responsive polymeric vesicles may find applications as nanocontainers in drug delivery, biosensing and biodetection.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalNature Materials
Volume3
Issue number3
Publication statusPublished - 2004

Fingerprint

Amphiphiles
polypropylene
Polyethylene glycols
Polypropylenes
Unilamellar Liposomes
Oxidation
oxidation
Liposomes
Hydrophobicity
hydrophobicity
Drug delivery
toxicity
glass transition temperature
Toxicity
Macros
sulfides
glycols
delivery
drugs
ethylene

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Napoli, A., Valentini, M., Tirelli, N., Müller, M., & Hubbell, J. A. (2004). Oxidation-responsive polymeric vesicles. Nature Materials, 3(3), 183-189.

Oxidation-responsive polymeric vesicles. / Napoli, Alessandro; Valentini, Massimiliano; Tirelli, Nicola; Müller, Martin; Hubbell, Jeffrey A.

In: Nature Materials, Vol. 3, No. 3, 2004, p. 183-189.

Research output: Contribution to journalArticle

Napoli, A, Valentini, M, Tirelli, N, Müller, M & Hubbell, JA 2004, 'Oxidation-responsive polymeric vesicles', Nature Materials, vol. 3, no. 3, pp. 183-189.
Napoli A, Valentini M, Tirelli N, Müller M, Hubbell JA. Oxidation-responsive polymeric vesicles. Nature Materials. 2004;3(3):183-189.
Napoli, Alessandro ; Valentini, Massimiliano ; Tirelli, Nicola ; Müller, Martin ; Hubbell, Jeffrey A. / Oxidation-responsive polymeric vesicles. In: Nature Materials. 2004 ; Vol. 3, No. 3. pp. 183-189.
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