Overexpression of EGFR protein in bruneian lung cancer patients

Yu Hao Han, Mas R W Abdul Hamid, Pemasiri Upali Telisinghe, Juniadah Binti Haji Hussin, Mohamed Mabruk

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Lung cancer is the leading cause of cancer death in Brunei Darussalam, accounting for almost 20% of the total. The epidermal growth factor receptor (EGFR) is a member of the erbB family of tyrosine kinase receptor proteins, which includes c-erbb2(HER2/neu), erb-B3, and erb-B4. EGFR overexpression is found in a third of all epithelial cancers, often associated with a poor prognosis. Materials and Methods: Protein expression of EGFR in 27 cases of lung cancer tissue samples and 9 cases of normal lung tissue samples was evaluated using an immunohistochemical approach. Results: The results demonstrated significant increase and overexpression of EGFR in Bruneian lung cancer tissue samples in comparison to normal lung tissue. However, there was no significant relationship between clinicopathologic variables (age and sex) of patients and EGFR protein expression. Conclusions: EGFR is overexpressed in Bruneian lung cancer patient tissue samples in comparison to normal lung tissue samples. This may indicate that EGFR protein over expression plays an important role in the genesis of this type of cancer in Brunei Darussalam.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume16
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Epidermal Growth Factor Receptor
Lung Neoplasms
Brunei
Proteins
Lung
Neoplasms
Receptor Protein-Tyrosine Kinases
Cause of Death

Keywords

  • EGFR
  • Immunohistichemistry
  • Lung cancer
  • Overexpression

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Overexpression of EGFR protein in bruneian lung cancer patients. / Han, Yu Hao; Abdul Hamid, Mas R W; Telisinghe, Pemasiri Upali; Hussin, Juniadah Binti Haji; Mabruk, Mohamed.

In: Asian Pacific Journal of Cancer Prevention, Vol. 16, No. 1, 2015, p. 233-237.

Research output: Contribution to journalArticle

Han, Yu Hao ; Abdul Hamid, Mas R W ; Telisinghe, Pemasiri Upali ; Hussin, Juniadah Binti Haji ; Mabruk, Mohamed. / Overexpression of EGFR protein in bruneian lung cancer patients. In: Asian Pacific Journal of Cancer Prevention. 2015 ; Vol. 16, No. 1. pp. 233-237.
@article{d2b06b2d49c646069c99b115eccaa731,
title = "Overexpression of EGFR protein in bruneian lung cancer patients",
abstract = "Background: Lung cancer is the leading cause of cancer death in Brunei Darussalam, accounting for almost 20{\%} of the total. The epidermal growth factor receptor (EGFR) is a member of the erbB family of tyrosine kinase receptor proteins, which includes c-erbb2(HER2/neu), erb-B3, and erb-B4. EGFR overexpression is found in a third of all epithelial cancers, often associated with a poor prognosis. Materials and Methods: Protein expression of EGFR in 27 cases of lung cancer tissue samples and 9 cases of normal lung tissue samples was evaluated using an immunohistochemical approach. Results: The results demonstrated significant increase and overexpression of EGFR in Bruneian lung cancer tissue samples in comparison to normal lung tissue. However, there was no significant relationship between clinicopathologic variables (age and sex) of patients and EGFR protein expression. Conclusions: EGFR is overexpressed in Bruneian lung cancer patient tissue samples in comparison to normal lung tissue samples. This may indicate that EGFR protein over expression plays an important role in the genesis of this type of cancer in Brunei Darussalam.",
keywords = "EGFR, Immunohistichemistry, Lung cancer, Overexpression",
author = "Han, {Yu Hao} and {Abdul Hamid}, {Mas R W} and Telisinghe, {Pemasiri Upali} and Hussin, {Juniadah Binti Haji} and Mohamed Mabruk",
year = "2015",
doi = "10.7314/APJCP.2015.16.1.233",
language = "English",
volume = "16",
pages = "233--237",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "1",

}

TY - JOUR

T1 - Overexpression of EGFR protein in bruneian lung cancer patients

AU - Han, Yu Hao

AU - Abdul Hamid, Mas R W

AU - Telisinghe, Pemasiri Upali

AU - Hussin, Juniadah Binti Haji

AU - Mabruk, Mohamed

PY - 2015

Y1 - 2015

N2 - Background: Lung cancer is the leading cause of cancer death in Brunei Darussalam, accounting for almost 20% of the total. The epidermal growth factor receptor (EGFR) is a member of the erbB family of tyrosine kinase receptor proteins, which includes c-erbb2(HER2/neu), erb-B3, and erb-B4. EGFR overexpression is found in a third of all epithelial cancers, often associated with a poor prognosis. Materials and Methods: Protein expression of EGFR in 27 cases of lung cancer tissue samples and 9 cases of normal lung tissue samples was evaluated using an immunohistochemical approach. Results: The results demonstrated significant increase and overexpression of EGFR in Bruneian lung cancer tissue samples in comparison to normal lung tissue. However, there was no significant relationship between clinicopathologic variables (age and sex) of patients and EGFR protein expression. Conclusions: EGFR is overexpressed in Bruneian lung cancer patient tissue samples in comparison to normal lung tissue samples. This may indicate that EGFR protein over expression plays an important role in the genesis of this type of cancer in Brunei Darussalam.

AB - Background: Lung cancer is the leading cause of cancer death in Brunei Darussalam, accounting for almost 20% of the total. The epidermal growth factor receptor (EGFR) is a member of the erbB family of tyrosine kinase receptor proteins, which includes c-erbb2(HER2/neu), erb-B3, and erb-B4. EGFR overexpression is found in a third of all epithelial cancers, often associated with a poor prognosis. Materials and Methods: Protein expression of EGFR in 27 cases of lung cancer tissue samples and 9 cases of normal lung tissue samples was evaluated using an immunohistochemical approach. Results: The results demonstrated significant increase and overexpression of EGFR in Bruneian lung cancer tissue samples in comparison to normal lung tissue. However, there was no significant relationship between clinicopathologic variables (age and sex) of patients and EGFR protein expression. Conclusions: EGFR is overexpressed in Bruneian lung cancer patient tissue samples in comparison to normal lung tissue samples. This may indicate that EGFR protein over expression plays an important role in the genesis of this type of cancer in Brunei Darussalam.

KW - EGFR

KW - Immunohistichemistry

KW - Lung cancer

KW - Overexpression

UR - http://www.scopus.com/inward/record.url?scp=84924233260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924233260&partnerID=8YFLogxK

U2 - 10.7314/APJCP.2015.16.1.233

DO - 10.7314/APJCP.2015.16.1.233

M3 - Article

VL - 16

SP - 233

EP - 237

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

SN - 1513-7368

IS - 1

ER -