Outcomes of triple-negative versus non-triple-negative breast cancers managed with breast-conserving therapy

Abu Bakar Hafeez Bhatti, Amina Iqbal Khan, Neelam Siddiqui, Nargis Muzaffar, Aamir Ali Syed, Mazhar Ali Shah, Arif Jamshed

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Triple negative breast cancer is associated with aggressive behavior and high risk of local and regional failure. Aggressive surgical intervention is considered suitable. This makes role of breast conserving therapy (BCT) debatable in these patients. The objective of this study was to compare outcome of BCT for triple negative versus non-triple negative breast cancer. Materials and Methods: Medical records of patients who underwent breast conserving therapy from 1999 to 2009 at Shaukat Khanum Cancer Hospital and had complete receptor status information were extracted. Patients were divided into triple negative breast cancer (TNBC) and non-TNBC. Patient characteristics, medical treatment modalities and adverse events were compared. Expected ive year locoregional recurrence free, disease free and overall survival was calculated. The Cox proportional hazard model was used to identify independent predictors of outcome. Results: A total of 194 patients with TNBC and 443 with non-TNBC were compared. Signiicant difference was present for age at presentation (p<0.0001), family history (p=0.005), grade (p<0.0001) and use of hormonal therapy (p<0.0001). The number of locoregional failures, distant failures and mortalities were not signiicantly different. No signiicant difference was present in 5 year locoregional recurrence free (96% vs 92%, p=0.3), disease free (75% vs 74%, p=0.7) and overall survival (78% vs 83%, p=0.2). On multivariate analysis, tumor size, nodal involvement and hormonal treatment were independent predictors of negative events. Conclusions: Breast conserving therapy has comparable outcomes for triple negative and non-triple negative breast cancers.

Original languageEnglish
Pages (from-to)2577-2581
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

Breast
Breast Neoplasms
Triple Negative Breast Neoplasms
Therapeutics
Cancer Care Facilities
Recurrence
Risk-Taking
Proportional Hazards Models
Disease-Free Survival
Medical Records
Multivariate Analysis
Survival
Mortality
Neoplasms

Keywords

  • Breast conservative therapy
  • Outcome
  • Triple negative breast cancer

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Outcomes of triple-negative versus non-triple-negative breast cancers managed with breast-conserving therapy. / Bhatti, Abu Bakar Hafeez; Khan, Amina Iqbal; Siddiqui, Neelam; Muzaffar, Nargis; Syed, Aamir Ali; Shah, Mazhar Ali; Jamshed, Arif.

In: Asian Pacific Journal of Cancer Prevention, Vol. 15, No. 6, 2014, p. 2577-2581.

Research output: Contribution to journalArticle

Bhatti, Abu Bakar Hafeez ; Khan, Amina Iqbal ; Siddiqui, Neelam ; Muzaffar, Nargis ; Syed, Aamir Ali ; Shah, Mazhar Ali ; Jamshed, Arif. / Outcomes of triple-negative versus non-triple-negative breast cancers managed with breast-conserving therapy. In: Asian Pacific Journal of Cancer Prevention. 2014 ; Vol. 15, No. 6. pp. 2577-2581.
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abstract = "Background: Triple negative breast cancer is associated with aggressive behavior and high risk of local and regional failure. Aggressive surgical intervention is considered suitable. This makes role of breast conserving therapy (BCT) debatable in these patients. The objective of this study was to compare outcome of BCT for triple negative versus non-triple negative breast cancer. Materials and Methods: Medical records of patients who underwent breast conserving therapy from 1999 to 2009 at Shaukat Khanum Cancer Hospital and had complete receptor status information were extracted. Patients were divided into triple negative breast cancer (TNBC) and non-TNBC. Patient characteristics, medical treatment modalities and adverse events were compared. Expected ive year locoregional recurrence free, disease free and overall survival was calculated. The Cox proportional hazard model was used to identify independent predictors of outcome. Results: A total of 194 patients with TNBC and 443 with non-TNBC were compared. Signiicant difference was present for age at presentation (p<0.0001), family history (p=0.005), grade (p<0.0001) and use of hormonal therapy (p<0.0001). The number of locoregional failures, distant failures and mortalities were not signiicantly different. No signiicant difference was present in 5 year locoregional recurrence free (96{\%} vs 92{\%}, p=0.3), disease free (75{\%} vs 74{\%}, p=0.7) and overall survival (78{\%} vs 83{\%}, p=0.2). On multivariate analysis, tumor size, nodal involvement and hormonal treatment were independent predictors of negative events. Conclusions: Breast conserving therapy has comparable outcomes for triple negative and non-triple negative breast cancers.",
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AU - Shah, Mazhar Ali

AU - Jamshed, Arif

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N2 - Background: Triple negative breast cancer is associated with aggressive behavior and high risk of local and regional failure. Aggressive surgical intervention is considered suitable. This makes role of breast conserving therapy (BCT) debatable in these patients. The objective of this study was to compare outcome of BCT for triple negative versus non-triple negative breast cancer. Materials and Methods: Medical records of patients who underwent breast conserving therapy from 1999 to 2009 at Shaukat Khanum Cancer Hospital and had complete receptor status information were extracted. Patients were divided into triple negative breast cancer (TNBC) and non-TNBC. Patient characteristics, medical treatment modalities and adverse events were compared. Expected ive year locoregional recurrence free, disease free and overall survival was calculated. The Cox proportional hazard model was used to identify independent predictors of outcome. Results: A total of 194 patients with TNBC and 443 with non-TNBC were compared. Signiicant difference was present for age at presentation (p<0.0001), family history (p=0.005), grade (p<0.0001) and use of hormonal therapy (p<0.0001). The number of locoregional failures, distant failures and mortalities were not signiicantly different. No signiicant difference was present in 5 year locoregional recurrence free (96% vs 92%, p=0.3), disease free (75% vs 74%, p=0.7) and overall survival (78% vs 83%, p=0.2). On multivariate analysis, tumor size, nodal involvement and hormonal treatment were independent predictors of negative events. Conclusions: Breast conserving therapy has comparable outcomes for triple negative and non-triple negative breast cancers.

AB - Background: Triple negative breast cancer is associated with aggressive behavior and high risk of local and regional failure. Aggressive surgical intervention is considered suitable. This makes role of breast conserving therapy (BCT) debatable in these patients. The objective of this study was to compare outcome of BCT for triple negative versus non-triple negative breast cancer. Materials and Methods: Medical records of patients who underwent breast conserving therapy from 1999 to 2009 at Shaukat Khanum Cancer Hospital and had complete receptor status information were extracted. Patients were divided into triple negative breast cancer (TNBC) and non-TNBC. Patient characteristics, medical treatment modalities and adverse events were compared. Expected ive year locoregional recurrence free, disease free and overall survival was calculated. The Cox proportional hazard model was used to identify independent predictors of outcome. Results: A total of 194 patients with TNBC and 443 with non-TNBC were compared. Signiicant difference was present for age at presentation (p<0.0001), family history (p=0.005), grade (p<0.0001) and use of hormonal therapy (p<0.0001). The number of locoregional failures, distant failures and mortalities were not signiicantly different. No signiicant difference was present in 5 year locoregional recurrence free (96% vs 92%, p=0.3), disease free (75% vs 74%, p=0.7) and overall survival (78% vs 83%, p=0.2). On multivariate analysis, tumor size, nodal involvement and hormonal treatment were independent predictors of negative events. Conclusions: Breast conserving therapy has comparable outcomes for triple negative and non-triple negative breast cancers.

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