Outcome of Adult Acute Lymphoblastic Leukemia

A Single Center Experience

M. Usman, I. Burney, A. Nasim, S. N. Adil, A. Salam, T. Siddiqui, M. Khurshid

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To study the outcomes of adult patients with acute lymphoblastic leukemia. Setting: Tertiary care hospital. Study Design: Retrospective analysis. Methods: Fifty eight adult patients (age >14years) diagnosed as cases of acute lymphoblastic leukemia were studied with respect to their clinical, morphological and immunopathological features at presentation and their relationship with treatment outcomes. Results: Forty five (77.5%) of the patients belonged to younger age group with male preponderance. The median age was 20 years and mean age was 25.1 years. Male to female ratio was 3:1. Common presenting signs were lymphadenopathy (17.2%), hepatomegaly (32.7%) and splenomegaly (62%). Laboratory features at presentation revealed: hemoglobin ≥10gm/dl in 18 (31%), WBC >50 × 10E9/L in 18 (31%), LDH more than 1000 IU/L in 44 (75.8%) of patients. Morphology revealed that FAB L1 was seen in 21 (37.2%) and L2 in 62 (32.7%). Immunophenotyping showed that 26 (61.9%) were early pre-B ALL, 6 (14.2%) were pre - B ALL and T-ALL were 10 (23.8%). Univariate analysis showed age more than 30 years, male gender, total leucocyte count >50×109/L and hemoglobin more than 10gm/dl to be risk factors for poor outcome. Multivariate analysis revealed age more than 30 years, male sex and total leucocyte count > 50 × 109/L are independent risk factors for poor survival. Patients were treated according to the MRCUKX and XII adult protocols. Thirteen (22.4%) patients died during induction therapy secondary to sepsis and progressive disease whereas 42(72.4%) patients achieved complete remission. Median survival was 18.6 months and 42% patients were alive at 5-years. Conclusion: Overall survival and disease free survival were comparable to those reported in literature. However, age more than 30 years, male gender and total leucocyte count >50 × 10 9/L had an adverse impact on overall survival.

Original languageEnglish
Pages (from-to)384-388
Number of pages5
JournalJournal of the Pakistan Medical Association
Volume53
Issue number9
Publication statusPublished - Sep 2003

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Leukocyte Count
Survival
Hemoglobins
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Immunophenotyping
Hepatomegaly
Splenomegaly
Tertiary Healthcare
Tertiary Care Centers
Disease-Free Survival
Sepsis
Multivariate Analysis
Retrospective Studies
Age Groups
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Usman, M., Burney, I., Nasim, A., Adil, S. N., Salam, A., Siddiqui, T., & Khurshid, M. (2003). Outcome of Adult Acute Lymphoblastic Leukemia: A Single Center Experience. Journal of the Pakistan Medical Association, 53(9), 384-388.

Outcome of Adult Acute Lymphoblastic Leukemia : A Single Center Experience. / Usman, M.; Burney, I.; Nasim, A.; Adil, S. N.; Salam, A.; Siddiqui, T.; Khurshid, M.

In: Journal of the Pakistan Medical Association, Vol. 53, No. 9, 09.2003, p. 384-388.

Research output: Contribution to journalArticle

Usman, M, Burney, I, Nasim, A, Adil, SN, Salam, A, Siddiqui, T & Khurshid, M 2003, 'Outcome of Adult Acute Lymphoblastic Leukemia: A Single Center Experience', Journal of the Pakistan Medical Association, vol. 53, no. 9, pp. 384-388.
Usman, M. ; Burney, I. ; Nasim, A. ; Adil, S. N. ; Salam, A. ; Siddiqui, T. ; Khurshid, M. / Outcome of Adult Acute Lymphoblastic Leukemia : A Single Center Experience. In: Journal of the Pakistan Medical Association. 2003 ; Vol. 53, No. 9. pp. 384-388.
@article{327b07a4564c4b9e9253422cfbfb26a5,
title = "Outcome of Adult Acute Lymphoblastic Leukemia: A Single Center Experience",
abstract = "Objective: To study the outcomes of adult patients with acute lymphoblastic leukemia. Setting: Tertiary care hospital. Study Design: Retrospective analysis. Methods: Fifty eight adult patients (age >14years) diagnosed as cases of acute lymphoblastic leukemia were studied with respect to their clinical, morphological and immunopathological features at presentation and their relationship with treatment outcomes. Results: Forty five (77.5{\%}) of the patients belonged to younger age group with male preponderance. The median age was 20 years and mean age was 25.1 years. Male to female ratio was 3:1. Common presenting signs were lymphadenopathy (17.2{\%}), hepatomegaly (32.7{\%}) and splenomegaly (62{\%}). Laboratory features at presentation revealed: hemoglobin ≥10gm/dl in 18 (31{\%}), WBC >50 × 10E9/L in 18 (31{\%}), LDH more than 1000 IU/L in 44 (75.8{\%}) of patients. Morphology revealed that FAB L1 was seen in 21 (37.2{\%}) and L2 in 62 (32.7{\%}). Immunophenotyping showed that 26 (61.9{\%}) were early pre-B ALL, 6 (14.2{\%}) were pre - B ALL and T-ALL were 10 (23.8{\%}). Univariate analysis showed age more than 30 years, male gender, total leucocyte count >50×109/L and hemoglobin more than 10gm/dl to be risk factors for poor outcome. Multivariate analysis revealed age more than 30 years, male sex and total leucocyte count > 50 × 109/L are independent risk factors for poor survival. Patients were treated according to the MRCUKX and XII adult protocols. Thirteen (22.4{\%}) patients died during induction therapy secondary to sepsis and progressive disease whereas 42(72.4{\%}) patients achieved complete remission. Median survival was 18.6 months and 42{\%} patients were alive at 5-years. Conclusion: Overall survival and disease free survival were comparable to those reported in literature. However, age more than 30 years, male gender and total leucocyte count >50 × 10 9/L had an adverse impact on overall survival.",
author = "M. Usman and I. Burney and A. Nasim and Adil, {S. N.} and A. Salam and T. Siddiqui and M. Khurshid",
year = "2003",
month = "9",
language = "English",
volume = "53",
pages = "384--388",
journal = "JPMA. The Journal of the Pakistan Medical Association",
issn = "0030-9982",
publisher = "Pakistan Medical Association",
number = "9",

}

TY - JOUR

T1 - Outcome of Adult Acute Lymphoblastic Leukemia

T2 - A Single Center Experience

AU - Usman, M.

AU - Burney, I.

AU - Nasim, A.

AU - Adil, S. N.

AU - Salam, A.

AU - Siddiqui, T.

AU - Khurshid, M.

PY - 2003/9

Y1 - 2003/9

N2 - Objective: To study the outcomes of adult patients with acute lymphoblastic leukemia. Setting: Tertiary care hospital. Study Design: Retrospective analysis. Methods: Fifty eight adult patients (age >14years) diagnosed as cases of acute lymphoblastic leukemia were studied with respect to their clinical, morphological and immunopathological features at presentation and their relationship with treatment outcomes. Results: Forty five (77.5%) of the patients belonged to younger age group with male preponderance. The median age was 20 years and mean age was 25.1 years. Male to female ratio was 3:1. Common presenting signs were lymphadenopathy (17.2%), hepatomegaly (32.7%) and splenomegaly (62%). Laboratory features at presentation revealed: hemoglobin ≥10gm/dl in 18 (31%), WBC >50 × 10E9/L in 18 (31%), LDH more than 1000 IU/L in 44 (75.8%) of patients. Morphology revealed that FAB L1 was seen in 21 (37.2%) and L2 in 62 (32.7%). Immunophenotyping showed that 26 (61.9%) were early pre-B ALL, 6 (14.2%) were pre - B ALL and T-ALL were 10 (23.8%). Univariate analysis showed age more than 30 years, male gender, total leucocyte count >50×109/L and hemoglobin more than 10gm/dl to be risk factors for poor outcome. Multivariate analysis revealed age more than 30 years, male sex and total leucocyte count > 50 × 109/L are independent risk factors for poor survival. Patients were treated according to the MRCUKX and XII adult protocols. Thirteen (22.4%) patients died during induction therapy secondary to sepsis and progressive disease whereas 42(72.4%) patients achieved complete remission. Median survival was 18.6 months and 42% patients were alive at 5-years. Conclusion: Overall survival and disease free survival were comparable to those reported in literature. However, age more than 30 years, male gender and total leucocyte count >50 × 10 9/L had an adverse impact on overall survival.

AB - Objective: To study the outcomes of adult patients with acute lymphoblastic leukemia. Setting: Tertiary care hospital. Study Design: Retrospective analysis. Methods: Fifty eight adult patients (age >14years) diagnosed as cases of acute lymphoblastic leukemia were studied with respect to their clinical, morphological and immunopathological features at presentation and their relationship with treatment outcomes. Results: Forty five (77.5%) of the patients belonged to younger age group with male preponderance. The median age was 20 years and mean age was 25.1 years. Male to female ratio was 3:1. Common presenting signs were lymphadenopathy (17.2%), hepatomegaly (32.7%) and splenomegaly (62%). Laboratory features at presentation revealed: hemoglobin ≥10gm/dl in 18 (31%), WBC >50 × 10E9/L in 18 (31%), LDH more than 1000 IU/L in 44 (75.8%) of patients. Morphology revealed that FAB L1 was seen in 21 (37.2%) and L2 in 62 (32.7%). Immunophenotyping showed that 26 (61.9%) were early pre-B ALL, 6 (14.2%) were pre - B ALL and T-ALL were 10 (23.8%). Univariate analysis showed age more than 30 years, male gender, total leucocyte count >50×109/L and hemoglobin more than 10gm/dl to be risk factors for poor outcome. Multivariate analysis revealed age more than 30 years, male sex and total leucocyte count > 50 × 109/L are independent risk factors for poor survival. Patients were treated according to the MRCUKX and XII adult protocols. Thirteen (22.4%) patients died during induction therapy secondary to sepsis and progressive disease whereas 42(72.4%) patients achieved complete remission. Median survival was 18.6 months and 42% patients were alive at 5-years. Conclusion: Overall survival and disease free survival were comparable to those reported in literature. However, age more than 30 years, male gender and total leucocyte count >50 × 10 9/L had an adverse impact on overall survival.

UR - http://www.scopus.com/inward/record.url?scp=0142089753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142089753&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 384

EP - 388

JO - JPMA. The Journal of the Pakistan Medical Association

JF - JPMA. The Journal of the Pakistan Medical Association

SN - 0030-9982

IS - 9

ER -