Origin and diversification of the human parasite Schistosoma mansoni

Jess A T Morgan, Randall J. Dejong, Grace O. Adeoye, Ebenezer D O Ansa, ConstanÇa S. Barbosa, Philippe Brémond, Italo M. Cesari, Nathalie Charbonnel, Lygia R. Corrêa, Godefroy Coulibaly, Paulo Sérgio D'Andrea, Cecilia Pereira De Souza, Michael J. Doenhoff, Sharon File, Mohamed A. Idris, R. Nino Incani, Philippe Jarne, Diana M S Karanja, Francis Kazibwe, John KpikpiNicholas J S Lwambo, Amadou Mabaye, Luiz A. Magalhães, Asanteli Makundi, Hélène Moné, Gabriel Mouahid, Gerald M. Muchemi, Ben N. Mungai, Mariama Séne, Vaughan Southgate, Louis Albert Tchuem Tchuenté, Andre Théron, Fouad Yousif, Eliana M. Zanotti-Magalhães, Gerald M. Mkoji, Eric S. Loker

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Schistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria, which largely determine the parasite's geographical range. How S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of S. mansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use, appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30-0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country.

Original languageEnglish
Pages (from-to)3889-3902
Number of pages14
JournalMolecular Ecology
Volume14
Issue number12
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Africa
  • Biomphalaria
  • Brazil
  • Phylogeography
  • Schistosomiasis
  • Slave trade

ASJC Scopus subject areas

  • Ecology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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  • Cite this

    Morgan, J. A. T., Dejong, R. J., Adeoye, G. O., Ansa, E. D. O., Barbosa, C. S., Brémond, P., Cesari, I. M., Charbonnel, N., Corrêa, L. R., Coulibaly, G., D'Andrea, P. S., De Souza, C. P., Doenhoff, M. J., File, S., Idris, M. A., Incani, R. N., Jarne, P., Karanja, D. M. S., Kazibwe, F., ... Loker, E. S. (2005). Origin and diversification of the human parasite Schistosoma mansoni. Molecular Ecology, 14(12), 3889-3902. https://doi.org/10.1111/j.1365-294X.2005.02709.x