Omega-3 fatty acids could alleviate the risks of traumatic brain injury-A mini review

Parvathy Kumar, Musthafa Essa, Samir Al-Adawi, Ghazi Dradekh, Mushtaq Memon, Mohammed Akbar, Thamilarasan Manivasagam

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) is an acquired brain trauma that occurs when any sudden trauma/injury causes damage to the brain. TBI is characterized by tissue damage and imbalance in the cerebral blood flow and metabolism. It has been established through laboratory experiments that the dietary supplementation of omega-3 fatty acids (FAs) could reduce the oxidative stress developed in brain due to TBI. The inclusion of omega-3 FA in diet could normalize the levels of brain-derived neurotrophic factor (BDNF), and thus, it could restore the survival of neuronal cells. BDNF improves the synaptic transmission by regulating synapsin 1 and cyclic adenosine monophosphate (cAMP) response element binding protein. The brain tissue analysis of TBI models supplemented with omega-3 polyunsaturated fatty acids (PUFAs) showed significantly reduced lipid peroxidation, nucleic acid and protein oxidation, thereby promoting neuronal and glial cell survival. Thus, omega-3 FA intake could be considered as a therapeutic option to reduce the secondary neuronal damages initiated by TBI.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalJournal of Traditional and Complementary Medicine
Volume4
Issue number2
DOIs
Publication statusPublished - 2014

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Keywords

  • Brain trauma
  • Neuronal damage
  • Oman
  • Omega-3 fatty acids
  • Traumatic brain injury

ASJC Scopus subject areas

  • Complementary and alternative medicine

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