TY - JOUR
T1 - Omega-3 fatty acids could alleviate the risks of traumatic brain injury-A mini review
AU - Kumar, Parvathy
AU - Essa, Musthafa
AU - Al-Adawi, Samir
AU - Dradekh, Ghazi
AU - Memon, Mushtaq
AU - Akbar, Mohammed
AU - Manivasagam, Thamilarasan
N1 - Funding Information:
The project was supported by a research grant from Research Council, Oman (Grant # RC/AGR/FOOD/11/01) to EMM, which is gratefully acknowledged. The PhD student fellowship offered to PVR by The Research Council, Oman (Grant # RC/AGR/FOOD/11/01) is highly acknowledged.
PY - 2014
Y1 - 2014
N2 - Traumatic brain injury (TBI) is an acquired brain trauma that occurs when any sudden trauma/injury causes damage to the brain. TBI is characterized by tissue damage and imbalance in the cerebral blood flow and metabolism. It has been established through laboratory experiments that the dietary supplementation of omega-3 fatty acids (FAs) could reduce the oxidative stress developed in brain due to TBI. The inclusion of omega-3 FA in diet could normalize the levels of brain-derived neurotrophic factor (BDNF), and thus, it could restore the survival of neuronal cells. BDNF improves the synaptic transmission by regulating synapsin 1 and cyclic adenosine monophosphate (cAMP) response element binding protein. The brain tissue analysis of TBI models supplemented with omega-3 polyunsaturated fatty acids (PUFAs) showed significantly reduced lipid peroxidation, nucleic acid and protein oxidation, thereby promoting neuronal and glial cell survival. Thus, omega-3 FA intake could be considered as a therapeutic option to reduce the secondary neuronal damages initiated by TBI.
AB - Traumatic brain injury (TBI) is an acquired brain trauma that occurs when any sudden trauma/injury causes damage to the brain. TBI is characterized by tissue damage and imbalance in the cerebral blood flow and metabolism. It has been established through laboratory experiments that the dietary supplementation of omega-3 fatty acids (FAs) could reduce the oxidative stress developed in brain due to TBI. The inclusion of omega-3 FA in diet could normalize the levels of brain-derived neurotrophic factor (BDNF), and thus, it could restore the survival of neuronal cells. BDNF improves the synaptic transmission by regulating synapsin 1 and cyclic adenosine monophosphate (cAMP) response element binding protein. The brain tissue analysis of TBI models supplemented with omega-3 polyunsaturated fatty acids (PUFAs) showed significantly reduced lipid peroxidation, nucleic acid and protein oxidation, thereby promoting neuronal and glial cell survival. Thus, omega-3 FA intake could be considered as a therapeutic option to reduce the secondary neuronal damages initiated by TBI.
KW - Brain trauma
KW - Neuronal damage
KW - Oman
KW - Omega-3 fatty acids
KW - Traumatic brain injury
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U2 - 10.4103/2225-4110.130374
DO - 10.4103/2225-4110.130374
M3 - Article
C2 - 24860731
AN - SCOPUS:84898981126
SN - 2225-4110
VL - 4
SP - 89
EP - 92
JO - Journal of Traditional and Complementary Medicine
JF - Journal of Traditional and Complementary Medicine
IS - 2
ER -