Omani date palm fruit varieties (Naghal and A'Seedi) inhibit amyloid beta protein fibrilization

A possible lead for therapeutic target to Alzheimer's disease

M. M. Essa, Amjaad S S Al-Ghaammari, Selvaraju Subash, Nejib Guizani, Amanat Ali

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Alzheimer's disease (AD) is the most common type of dementia characterized by loss of memory, learning, daily routine activities and neuronal cell damage. This neuronal damage may occur due to the accumulation of a peptide named amyloid beta protein (Aβ) outside the neuronal cells leading to neuronal cell death. The mechanism of aggregation and fibrillization of Aβ is still unclear. Identification of compounds that can inhibit Aβ fibrillization is of great significance for possible therapeutic and preventive measures for AD. Date palm (Phoenix dactylifera) fruits, DPF) are used since centuries in Middle Eastern countries for nutritional/medicinal purposes. Present study was designed to investigate the effect of two different Omani date palm fruit varieties (Naghal and A'Seedi) at four different growth stages (Khalal, Biser, Rutab and Tamar) on the inhibition of Aβ fibrillization under in vitro conditions analysed by Thioflavin T fluorescence method. Results showed that 20μg of gallic acid equivalent (GAE) methanolic extract of both DPF varieties offered a variable rate of inhibition on Aβ fibrillization due to their varying levels of total poly phenols, total flavonoids and total antioxidant capacity. The highest inhibition rate of Aβ fibrillization was shown in the khalal stage for Naghal and in Biser stage for A'Seedi. Our data indicate that Omani date palm fruits could offer anti-amyloidogenic activity, which may be due to their variable bioactive components and antioxidant properties, which confirm the previous reports. However, the exact mechanism of action is still unknown and further preclinical and clinical studies are warranted.

Original languageEnglish
Title of host publicationFood and Brain Health
PublisherNova Science Publishers, Inc.
Pages327-338
Number of pages12
ISBN (Print)9781631177385, 9781631177347
Publication statusPublished - Jan 1 2014

Fingerprint

Phoenix dactylifera
Amyloid beta-Peptides
amyloid
Alzheimer disease
Alzheimer Disease
therapeutics
fruits
neurons
proteins
Antioxidants
antioxidants
Gallic Acid
dementia
Phenols
Memory Disorders
Staphylococcal Protein A
Therapeutics
gallic acid
Flavonoids
phenols

Keywords

  • Alzheimer's disease
  • Amyloid beta fibrillization
  • Oman
  • Phoenix dactylifera
  • Total antioxidant capacity
  • Total flavonoids
  • Total polyphenols

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Omani date palm fruit varieties (Naghal and A'Seedi) inhibit amyloid beta protein fibrilization : A possible lead for therapeutic target to Alzheimer's disease. / Essa, M. M.; Al-Ghaammari, Amjaad S S; Subash, Selvaraju; Guizani, Nejib; Ali, Amanat.

Food and Brain Health. Nova Science Publishers, Inc., 2014. p. 327-338.

Research output: Chapter in Book/Report/Conference proceedingChapter

@inbook{d4432bea8b2348f08287bae62a8bcc7c,
title = "Omani date palm fruit varieties (Naghal and A'Seedi) inhibit amyloid beta protein fibrilization: A possible lead for therapeutic target to Alzheimer's disease",
abstract = "Alzheimer's disease (AD) is the most common type of dementia characterized by loss of memory, learning, daily routine activities and neuronal cell damage. This neuronal damage may occur due to the accumulation of a peptide named amyloid beta protein (Aβ) outside the neuronal cells leading to neuronal cell death. The mechanism of aggregation and fibrillization of Aβ is still unclear. Identification of compounds that can inhibit Aβ fibrillization is of great significance for possible therapeutic and preventive measures for AD. Date palm (Phoenix dactylifera) fruits, DPF) are used since centuries in Middle Eastern countries for nutritional/medicinal purposes. Present study was designed to investigate the effect of two different Omani date palm fruit varieties (Naghal and A'Seedi) at four different growth stages (Khalal, Biser, Rutab and Tamar) on the inhibition of Aβ fibrillization under in vitro conditions analysed by Thioflavin T fluorescence method. Results showed that 20μg of gallic acid equivalent (GAE) methanolic extract of both DPF varieties offered a variable rate of inhibition on Aβ fibrillization due to their varying levels of total poly phenols, total flavonoids and total antioxidant capacity. The highest inhibition rate of Aβ fibrillization was shown in the khalal stage for Naghal and in Biser stage for A'Seedi. Our data indicate that Omani date palm fruits could offer anti-amyloidogenic activity, which may be due to their variable bioactive components and antioxidant properties, which confirm the previous reports. However, the exact mechanism of action is still unknown and further preclinical and clinical studies are warranted.",
keywords = "Alzheimer's disease, Amyloid beta fibrillization, Oman, Phoenix dactylifera, Total antioxidant capacity, Total flavonoids, Total polyphenols",
author = "Essa, {M. M.} and Al-Ghaammari, {Amjaad S S} and Selvaraju Subash and Nejib Guizani and Amanat Ali",
year = "2014",
month = "1",
day = "1",
language = "English",
isbn = "9781631177385",
pages = "327--338",
booktitle = "Food and Brain Health",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Omani date palm fruit varieties (Naghal and A'Seedi) inhibit amyloid beta protein fibrilization

T2 - A possible lead for therapeutic target to Alzheimer's disease

AU - Essa, M. M.

AU - Al-Ghaammari, Amjaad S S

AU - Subash, Selvaraju

AU - Guizani, Nejib

AU - Ali, Amanat

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Alzheimer's disease (AD) is the most common type of dementia characterized by loss of memory, learning, daily routine activities and neuronal cell damage. This neuronal damage may occur due to the accumulation of a peptide named amyloid beta protein (Aβ) outside the neuronal cells leading to neuronal cell death. The mechanism of aggregation and fibrillization of Aβ is still unclear. Identification of compounds that can inhibit Aβ fibrillization is of great significance for possible therapeutic and preventive measures for AD. Date palm (Phoenix dactylifera) fruits, DPF) are used since centuries in Middle Eastern countries for nutritional/medicinal purposes. Present study was designed to investigate the effect of two different Omani date palm fruit varieties (Naghal and A'Seedi) at four different growth stages (Khalal, Biser, Rutab and Tamar) on the inhibition of Aβ fibrillization under in vitro conditions analysed by Thioflavin T fluorescence method. Results showed that 20μg of gallic acid equivalent (GAE) methanolic extract of both DPF varieties offered a variable rate of inhibition on Aβ fibrillization due to their varying levels of total poly phenols, total flavonoids and total antioxidant capacity. The highest inhibition rate of Aβ fibrillization was shown in the khalal stage for Naghal and in Biser stage for A'Seedi. Our data indicate that Omani date palm fruits could offer anti-amyloidogenic activity, which may be due to their variable bioactive components and antioxidant properties, which confirm the previous reports. However, the exact mechanism of action is still unknown and further preclinical and clinical studies are warranted.

AB - Alzheimer's disease (AD) is the most common type of dementia characterized by loss of memory, learning, daily routine activities and neuronal cell damage. This neuronal damage may occur due to the accumulation of a peptide named amyloid beta protein (Aβ) outside the neuronal cells leading to neuronal cell death. The mechanism of aggregation and fibrillization of Aβ is still unclear. Identification of compounds that can inhibit Aβ fibrillization is of great significance for possible therapeutic and preventive measures for AD. Date palm (Phoenix dactylifera) fruits, DPF) are used since centuries in Middle Eastern countries for nutritional/medicinal purposes. Present study was designed to investigate the effect of two different Omani date palm fruit varieties (Naghal and A'Seedi) at four different growth stages (Khalal, Biser, Rutab and Tamar) on the inhibition of Aβ fibrillization under in vitro conditions analysed by Thioflavin T fluorescence method. Results showed that 20μg of gallic acid equivalent (GAE) methanolic extract of both DPF varieties offered a variable rate of inhibition on Aβ fibrillization due to their varying levels of total poly phenols, total flavonoids and total antioxidant capacity. The highest inhibition rate of Aβ fibrillization was shown in the khalal stage for Naghal and in Biser stage for A'Seedi. Our data indicate that Omani date palm fruits could offer anti-amyloidogenic activity, which may be due to their variable bioactive components and antioxidant properties, which confirm the previous reports. However, the exact mechanism of action is still unknown and further preclinical and clinical studies are warranted.

KW - Alzheimer's disease

KW - Amyloid beta fibrillization

KW - Oman

KW - Phoenix dactylifera

KW - Total antioxidant capacity

KW - Total flavonoids

KW - Total polyphenols

UR - http://www.scopus.com/inward/record.url?scp=84949603955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949603955&partnerID=8YFLogxK

M3 - Chapter

SN - 9781631177385

SN - 9781631177347

SP - 327

EP - 338

BT - Food and Brain Health

PB - Nova Science Publishers, Inc.

ER -