Off-line optimization of the separation of 2,4-dinitrophenylhydrazones by gas chromatography using chemometric techniques

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An off-line optimization technique based on soft modeling methods has been used to determine the optimum conditions for the separation of eight carbonyl-2,4-dinitrophenylhydrazones by gas chromatography equipped with a nitrogen-phosphorous detector. In this method theoretical simulations of peak retention time and peak width at base-line are coupled to a factorial design to map the chromatographic response surface. The calculated retention times from isothermal data have been used to calculate the chromatographic parameters. A full 33 factorial design was used to locate the optimum conditions for the temperature program, utilizing initial oven temperature, Ti, the programming rate for the first ramp, PR1, and the programming rate for the second ramp, PR2 as independent variables. The optimum conditions obtained for these parameters were: Ti, 140 °C; PR1, 12 °C min-1; PR2, 8 °C min -1. The maximum analysis times achieved by this optimum was 10.6 min.

Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalTalanta
Volume56
Issue number1
DOIs
Publication statusPublished - Jan 4 2002

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Gas chromatography
Gas Chromatography
Architectural Accessibility
Ovens
Temperature
Nitrogen
Detectors
2,4-dinitrophenylhydrazone

Keywords

  • 2,4-Dinitrophenylhydrazones
  • Experimental design
  • Gas chromatography
  • Optimization

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

Off-line optimization of the separation of 2,4-dinitrophenylhydrazones by gas chromatography using chemometric techniques. / Suliman, F. E O.

In: Talanta, Vol. 56, No. 1, 04.01.2002, p. 175-183.

Research output: Contribution to journalArticle

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