Novel amino acid-based ionic liquid analogues

Neutral hydroxylic and sulfur-containing amino acids

Farouq S. Mjalli, Rashid Al-Hajri, Ala'a Al-Muhtaseb, Omar Ahmed, Maddela Nagaraju

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Deep eutectic solvents (DESs) have shown potential promise for various industrial applications. Abundant research works were carried out on Type III DES employing choline chloride as the quaternary ammonium salt in combination with a variety of hydrogen bond donors (HBDs). Despite the fact that they are cheap, biodegradable, and have a wide application in food, polymer, and pharmaceutical industries, amino acids have not been utilized as HBD for the synthesis of DES. In this work, different ammonium-based salts are used to synthesize different amino acid-based DES systems. Four different amino acids are considered, two of which are neutral amino acids, namely L-serine and L-threonine, while the other two are based on the sulfur-containing amino acids, namely L-methionine and L-cysteine. The successful DESs were characterized in terms of their physical properties. The melting point, density, viscosity, surface tension, refractive index, conductivity, and pH were measured for the successful DES systems at different temperatures ranging from 303.15 to 353.15K. The introduction of such novel DES opens the door for performing more work on utilizing them for various chemical, biochemical, and pharmaceutical applications.

Original languageEnglish
JournalAsia-Pacific Journal of Chemical Engineering
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Ionic Liquids
Ionic liquids
Sulfur
Eutectics
Amino acids
amino acid
sulfur
Amino Acids
Ammonium Compounds
Drug products
Hydrogen bonds
ammonium
Salts
hydrogen
salt
Neutral Amino Acids
pharmaceutical industry
surface tension
research work
Threonine

Keywords

  • Amino acids
  • Eutectic
  • Ionic liquids
  • Methionine
  • Serine
  • Threonine

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal

Cite this

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abstract = "Deep eutectic solvents (DESs) have shown potential promise for various industrial applications. Abundant research works were carried out on Type III DES employing choline chloride as the quaternary ammonium salt in combination with a variety of hydrogen bond donors (HBDs). Despite the fact that they are cheap, biodegradable, and have a wide application in food, polymer, and pharmaceutical industries, amino acids have not been utilized as HBD for the synthesis of DES. In this work, different ammonium-based salts are used to synthesize different amino acid-based DES systems. Four different amino acids are considered, two of which are neutral amino acids, namely L-serine and L-threonine, while the other two are based on the sulfur-containing amino acids, namely L-methionine and L-cysteine. The successful DESs were characterized in terms of their physical properties. The melting point, density, viscosity, surface tension, refractive index, conductivity, and pH were measured for the successful DES systems at different temperatures ranging from 303.15 to 353.15K. The introduction of such novel DES opens the door for performing more work on utilizing them for various chemical, biochemical, and pharmaceutical applications.",
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T1 - Novel amino acid-based ionic liquid analogues

T2 - Neutral hydroxylic and sulfur-containing amino acids

AU - Mjalli, Farouq S.

AU - Al-Hajri, Rashid

AU - Al-Muhtaseb, Ala'a

AU - Ahmed, Omar

AU - Nagaraju, Maddela

PY - 2016

Y1 - 2016

N2 - Deep eutectic solvents (DESs) have shown potential promise for various industrial applications. Abundant research works were carried out on Type III DES employing choline chloride as the quaternary ammonium salt in combination with a variety of hydrogen bond donors (HBDs). Despite the fact that they are cheap, biodegradable, and have a wide application in food, polymer, and pharmaceutical industries, amino acids have not been utilized as HBD for the synthesis of DES. In this work, different ammonium-based salts are used to synthesize different amino acid-based DES systems. Four different amino acids are considered, two of which are neutral amino acids, namely L-serine and L-threonine, while the other two are based on the sulfur-containing amino acids, namely L-methionine and L-cysteine. The successful DESs were characterized in terms of their physical properties. The melting point, density, viscosity, surface tension, refractive index, conductivity, and pH were measured for the successful DES systems at different temperatures ranging from 303.15 to 353.15K. The introduction of such novel DES opens the door for performing more work on utilizing them for various chemical, biochemical, and pharmaceutical applications.

AB - Deep eutectic solvents (DESs) have shown potential promise for various industrial applications. Abundant research works were carried out on Type III DES employing choline chloride as the quaternary ammonium salt in combination with a variety of hydrogen bond donors (HBDs). Despite the fact that they are cheap, biodegradable, and have a wide application in food, polymer, and pharmaceutical industries, amino acids have not been utilized as HBD for the synthesis of DES. In this work, different ammonium-based salts are used to synthesize different amino acid-based DES systems. Four different amino acids are considered, two of which are neutral amino acids, namely L-serine and L-threonine, while the other two are based on the sulfur-containing amino acids, namely L-methionine and L-cysteine. The successful DESs were characterized in terms of their physical properties. The melting point, density, viscosity, surface tension, refractive index, conductivity, and pH were measured for the successful DES systems at different temperatures ranging from 303.15 to 353.15K. The introduction of such novel DES opens the door for performing more work on utilizing them for various chemical, biochemical, and pharmaceutical applications.

KW - Amino acids

KW - Eutectic

KW - Ionic liquids

KW - Methionine

KW - Serine

KW - Threonine

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