Nonalcoholic fatty liver disease: Noninvasive methods of diagnosing hepatic steatosis

Rasha Alshaalan, Murad Aljiffry, Said Al-Busafi, Peter Metrakos, Mazen Hassanain

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Hepatic steatosis is the buildup of lipids within hepatocytes. It is the simplest stage in nonalcoholic fatty liver disease (NAFLD). It occurs in approximately 30% of the general population and as much as 90% of the obese population in the United States. It may progress to nonalcoholic steatohepatitis, which is a state of hepatocellular inflammation and damage in response to the accumulated fat. Liver biopsy remains the gold standard tool to diagnose and stage NAFLD. However, it comes with the risk of complications ranging from simple pain to life-threatening bleeding. It is also associated with sampling error. For these reasons, a variety of noninvasive radiological markers, including ultrasound, computed tomography, magnetic resonance spectroscopy, and the controlled attenuation parameter using transient elastography and Xenon-133 scan have been proposed to increase our ability to diagnose NAFLD, hence avoiding liver biopsy. The aim of this review is to discuss the utility and accuracy of using available noninvasive diagnostic modalities for fatty liver in NAFLD.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalSaudi Journal of Gastroenterology
Volume21
Issue number2
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Liver
Biopsy
Elasticity Imaging Techniques
Xenon
Aptitude
Selection Bias
Fatty Liver
Population
Hepatocytes
Magnetic Resonance Spectroscopy
Fats
Tomography
Non-alcoholic Fatty Liver Disease
Hemorrhage
Inflammation
Lipids
Pain

Keywords

  • Hepatic steatosis
  • nonalcoholic fatty liver
  • noninvasive methods for hepatic steatosis assessment

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Nonalcoholic fatty liver disease : Noninvasive methods of diagnosing hepatic steatosis. / Alshaalan, Rasha; Aljiffry, Murad; Al-Busafi, Said; Metrakos, Peter; Hassanain, Mazen.

In: Saudi Journal of Gastroenterology, Vol. 21, No. 2, 01.03.2015, p. 64-70.

Research output: Contribution to journalReview article

Alshaalan, Rasha ; Aljiffry, Murad ; Al-Busafi, Said ; Metrakos, Peter ; Hassanain, Mazen. / Nonalcoholic fatty liver disease : Noninvasive methods of diagnosing hepatic steatosis. In: Saudi Journal of Gastroenterology. 2015 ; Vol. 21, No. 2. pp. 64-70.
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