Abstract
We have investigated whether 'at risk' subjects who did not respond serologically during a pre-study vaccination with a commercial egg grown influenza sub-unit vaccine would respond to a subsequent vaccination with either a single dose of MDCK cell grown influenza vaccine or a standard egg grown influenza vaccine containing the same virus strains. We studied 48 non-responder subjects with a mean age 67.5, range: 34-82 years. In this non-responder group the increased immune response that was detected after boosting with an MDCK cell derived vaccine response was variable and relatively modest, except for the A/Texas strain in the vaccine. The proportion of subjects, with an HI titre of ≥40 (protective antibody titre) increased from 50 to 83% (A/Texas strain), from 13 to 25% (B/Harbin strain) and from 38 to 46% (A/Wuhan strain). In comparison a booster vaccination with egg-derived influenza vaccine resulted in an increase immune response with an HI antibody titre ≥40 for two of the three strains, namely from 17 to 58% for the B/Harbin strain and from 8 to 33% for the A/Wuhan strain.
| Original language | English |
|---|---|
| Pages (from-to) | 2743-2746 |
| Number of pages | 4 |
| Journal | Vaccine |
| Volume | 21 |
| Issue number | 21-22 |
| DOIs | |
| Publication status | Published - Jun 20 2003 |
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Keywords
- Cell grown vaccine
- Influenza vaccine seroconvert
- MDCK
- Non-responders
ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)
Cite this
Non-responders to egg grown influenza vaccine seroconvert after booster immunization with MDCK cell grown vaccine. / Oxford, John S.; Al-Jabri, Ali A.; Lambkin, Robert; Palache, A. M.; Fleming, D. M.
In: Vaccine, Vol. 21, No. 21-22, 20.06.2003, p. 2743-2746.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Non-responders to egg grown influenza vaccine seroconvert after booster immunization with MDCK cell grown vaccine
AU - Oxford, John S.
AU - Al-Jabri, Ali A.
AU - Lambkin, Robert
AU - Palache, A. M.
AU - Fleming, D. M.
PY - 2003/6/20
Y1 - 2003/6/20
N2 - We have investigated whether 'at risk' subjects who did not respond serologically during a pre-study vaccination with a commercial egg grown influenza sub-unit vaccine would respond to a subsequent vaccination with either a single dose of MDCK cell grown influenza vaccine or a standard egg grown influenza vaccine containing the same virus strains. We studied 48 non-responder subjects with a mean age 67.5, range: 34-82 years. In this non-responder group the increased immune response that was detected after boosting with an MDCK cell derived vaccine response was variable and relatively modest, except for the A/Texas strain in the vaccine. The proportion of subjects, with an HI titre of ≥40 (protective antibody titre) increased from 50 to 83% (A/Texas strain), from 13 to 25% (B/Harbin strain) and from 38 to 46% (A/Wuhan strain). In comparison a booster vaccination with egg-derived influenza vaccine resulted in an increase immune response with an HI antibody titre ≥40 for two of the three strains, namely from 17 to 58% for the B/Harbin strain and from 8 to 33% for the A/Wuhan strain.
AB - We have investigated whether 'at risk' subjects who did not respond serologically during a pre-study vaccination with a commercial egg grown influenza sub-unit vaccine would respond to a subsequent vaccination with either a single dose of MDCK cell grown influenza vaccine or a standard egg grown influenza vaccine containing the same virus strains. We studied 48 non-responder subjects with a mean age 67.5, range: 34-82 years. In this non-responder group the increased immune response that was detected after boosting with an MDCK cell derived vaccine response was variable and relatively modest, except for the A/Texas strain in the vaccine. The proportion of subjects, with an HI titre of ≥40 (protective antibody titre) increased from 50 to 83% (A/Texas strain), from 13 to 25% (B/Harbin strain) and from 38 to 46% (A/Wuhan strain). In comparison a booster vaccination with egg-derived influenza vaccine resulted in an increase immune response with an HI antibody titre ≥40 for two of the three strains, namely from 17 to 58% for the B/Harbin strain and from 8 to 33% for the A/Wuhan strain.
KW - Cell grown vaccine
KW - Influenza vaccine seroconvert
KW - MDCK
KW - Non-responders
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U2 - 10.1016/S0264-410X(03)00214-7
DO - 10.1016/S0264-410X(03)00214-7
M3 - Article
VL - 21
SP - 2743
EP - 2746
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 21-22
ER -