Non-high-density lipoprotein cholesterol target achievement in patients on lipid-lowering drugs and stratified by triglyceride levels in the Arabian Gulf

Khamis Al-Hashmi, Ibrahim Al-Zakwani, Wael Al Mahmeed, Mohammed Arafah, Ali T. Al-Hinai, Abdullah Shehab, Omer Al Tamimi, Mahmoud Al Awadhi, Shorook Al Herz, Faisal Al Anazi, Khalid Al Nemer, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali, Obaid Al Jassim, Omar Al Hallaq, Fahad Omar Ahmed S BaslaibHaitham Amin, Raul D. Santos, Khalid Al-Waili, Khalid Al-Rasadi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Atherogenic dyslipidemia is highly prevalent in the Arabian Gulf. Non-high-density lipoprotein cholesterol (non-HDL-C) reduction has been proposed as an additional goal to low-density lipoprotein cholesterol (LDL-C) lowering to prevent atherosclerotic cardiovascular disease (ASCVD). Data on non-HDL-C goal attainment in patients with high triglycerides (TGs) on lipid-lowering drugs (LLDs) in the region is scarce. Objective: Evaluate non-HDL-C target attainment according to the National Lipid Association in patients on LLDs stratified by TG (200 [2.26] mg/dL [mmol/L]) levels in the Arabian Gulf. Methods: Overall, 4383 patients on LLD treatment from 6 Middle Eastern countries participating in the Centralized Pan-Middle East Survey on the Undertreatment of Hypercholesterolemia study were evaluated. Patients were classified according to TG levels and ASCVD risk. Results: The overall non-HDL-C goal attainment was 41% of the subjects. Non-HDL-C goal was less likely attained in patients with high TGs (12% vs 27% vs 55%; P <.001). Very high ASCVD risk patients with high TGs attained less their non-HDL-C targets compared with those with lower TG levels (8% vs 23% vs 51%; P <.001). Similarly, high ASCVD risk patients with high TGs also failed more in attaining non-HDL-C targets compared with those with lower TGs (26% vs 42% vs 69%; P <.001). In addition, those with high TG also succeeded less in attaining LDL-C and apolipoprotein B goals (P <.001). Conclusions: A large proportion of very high and high ASCVD patients on LLDs in the Arabian Gulf are not at recommended non-HDL-C targets and hence remain at a substantial residual risk.

Original languageEnglish
JournalJournal of Clinical Lipidology
DOIs
Publication statusAccepted/In press - Aug 25 2015

Fingerprint

Triglycerides
Lipids
Pharmaceutical Preparations
Cardiovascular Diseases
LDL Cholesterol
lipoprotein cholesterol
Middle East
Apolipoproteins B
Dyslipidemias
Hypercholesterolemia

Keywords

  • Apolipoprotein B
  • Cardiovascular diseases
  • Diabetes mellitus
  • HDL cholesterol
  • LDL cholesterol
  • Middle East
  • Non-HDL cholesterol
  • Triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

Cite this

Non-high-density lipoprotein cholesterol target achievement in patients on lipid-lowering drugs and stratified by triglyceride levels in the Arabian Gulf. / Al-Hashmi, Khamis; Al-Zakwani, Ibrahim; Al Mahmeed, Wael; Arafah, Mohammed; Al-Hinai, Ali T.; Shehab, Abdullah; Al Tamimi, Omer; Al Awadhi, Mahmoud; Al Herz, Shorook; Al Anazi, Faisal; Al Nemer, Khalid; Metwally, Othman; Alkhadra, Akram; Fakhry, Mohammed; Elghetany, Hossam; Medani, Abdel Razak; Yusufali, Afzal Hussein; Al Jassim, Obaid; Al Hallaq, Omar; Baslaib, Fahad Omar Ahmed S; Amin, Haitham; Santos, Raul D.; Al-Waili, Khalid; Al-Rasadi, Khalid.

In: Journal of Clinical Lipidology, 25.08.2015.

Research output: Contribution to journalArticle

Al-Hashmi, K, Al-Zakwani, I, Al Mahmeed, W, Arafah, M, Al-Hinai, AT, Shehab, A, Al Tamimi, O, Al Awadhi, M, Al Herz, S, Al Anazi, F, Al Nemer, K, Metwally, O, Alkhadra, A, Fakhry, M, Elghetany, H, Medani, AR, Yusufali, AH, Al Jassim, O, Al Hallaq, O, Baslaib, FOAS, Amin, H, Santos, RD, Al-Waili, K & Al-Rasadi, K 2015, 'Non-high-density lipoprotein cholesterol target achievement in patients on lipid-lowering drugs and stratified by triglyceride levels in the Arabian Gulf', Journal of Clinical Lipidology. https://doi.org/10.1016/j.jacl.2015.12.021
Al-Hashmi, Khamis ; Al-Zakwani, Ibrahim ; Al Mahmeed, Wael ; Arafah, Mohammed ; Al-Hinai, Ali T. ; Shehab, Abdullah ; Al Tamimi, Omer ; Al Awadhi, Mahmoud ; Al Herz, Shorook ; Al Anazi, Faisal ; Al Nemer, Khalid ; Metwally, Othman ; Alkhadra, Akram ; Fakhry, Mohammed ; Elghetany, Hossam ; Medani, Abdel Razak ; Yusufali, Afzal Hussein ; Al Jassim, Obaid ; Al Hallaq, Omar ; Baslaib, Fahad Omar Ahmed S ; Amin, Haitham ; Santos, Raul D. ; Al-Waili, Khalid ; Al-Rasadi, Khalid. / Non-high-density lipoprotein cholesterol target achievement in patients on lipid-lowering drugs and stratified by triglyceride levels in the Arabian Gulf. In: Journal of Clinical Lipidology. 2015.
@article{4423bb203a6a461f90515ee7b472834f,
title = "Non-high-density lipoprotein cholesterol target achievement in patients on lipid-lowering drugs and stratified by triglyceride levels in the Arabian Gulf",
abstract = "Background: Atherogenic dyslipidemia is highly prevalent in the Arabian Gulf. Non-high-density lipoprotein cholesterol (non-HDL-C) reduction has been proposed as an additional goal to low-density lipoprotein cholesterol (LDL-C) lowering to prevent atherosclerotic cardiovascular disease (ASCVD). Data on non-HDL-C goal attainment in patients with high triglycerides (TGs) on lipid-lowering drugs (LLDs) in the region is scarce. Objective: Evaluate non-HDL-C target attainment according to the National Lipid Association in patients on LLDs stratified by TG (200 [2.26] mg/dL [mmol/L]) levels in the Arabian Gulf. Methods: Overall, 4383 patients on LLD treatment from 6 Middle Eastern countries participating in the Centralized Pan-Middle East Survey on the Undertreatment of Hypercholesterolemia study were evaluated. Patients were classified according to TG levels and ASCVD risk. Results: The overall non-HDL-C goal attainment was 41{\%} of the subjects. Non-HDL-C goal was less likely attained in patients with high TGs (12{\%} vs 27{\%} vs 55{\%}; P <.001). Very high ASCVD risk patients with high TGs attained less their non-HDL-C targets compared with those with lower TG levels (8{\%} vs 23{\%} vs 51{\%}; P <.001). Similarly, high ASCVD risk patients with high TGs also failed more in attaining non-HDL-C targets compared with those with lower TGs (26{\%} vs 42{\%} vs 69{\%}; P <.001). In addition, those with high TG also succeeded less in attaining LDL-C and apolipoprotein B goals (P <.001). Conclusions: A large proportion of very high and high ASCVD patients on LLDs in the Arabian Gulf are not at recommended non-HDL-C targets and hence remain at a substantial residual risk.",
keywords = "Apolipoprotein B, Cardiovascular diseases, Diabetes mellitus, HDL cholesterol, LDL cholesterol, Middle East, Non-HDL cholesterol, Triglycerides",
author = "Khamis Al-Hashmi and Ibrahim Al-Zakwani and {Al Mahmeed}, Wael and Mohammed Arafah and Al-Hinai, {Ali T.} and Abdullah Shehab and {Al Tamimi}, Omer and {Al Awadhi}, Mahmoud and {Al Herz}, Shorook and {Al Anazi}, Faisal and {Al Nemer}, Khalid and Othman Metwally and Akram Alkhadra and Mohammed Fakhry and Hossam Elghetany and Medani, {Abdel Razak} and Yusufali, {Afzal Hussein} and {Al Jassim}, Obaid and {Al Hallaq}, Omar and Baslaib, {Fahad Omar Ahmed S} and Haitham Amin and Santos, {Raul D.} and Khalid Al-Waili and Khalid Al-Rasadi",
year = "2015",
month = "8",
day = "25",
doi = "10.1016/j.jacl.2015.12.021",
language = "English",
journal = "Journal of Clinical Lipidology",
issn = "1933-2874",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Non-high-density lipoprotein cholesterol target achievement in patients on lipid-lowering drugs and stratified by triglyceride levels in the Arabian Gulf

AU - Al-Hashmi, Khamis

AU - Al-Zakwani, Ibrahim

AU - Al Mahmeed, Wael

AU - Arafah, Mohammed

AU - Al-Hinai, Ali T.

AU - Shehab, Abdullah

AU - Al Tamimi, Omer

AU - Al Awadhi, Mahmoud

AU - Al Herz, Shorook

AU - Al Anazi, Faisal

AU - Al Nemer, Khalid

AU - Metwally, Othman

AU - Alkhadra, Akram

AU - Fakhry, Mohammed

AU - Elghetany, Hossam

AU - Medani, Abdel Razak

AU - Yusufali, Afzal Hussein

AU - Al Jassim, Obaid

AU - Al Hallaq, Omar

AU - Baslaib, Fahad Omar Ahmed S

AU - Amin, Haitham

AU - Santos, Raul D.

AU - Al-Waili, Khalid

AU - Al-Rasadi, Khalid

PY - 2015/8/25

Y1 - 2015/8/25

N2 - Background: Atherogenic dyslipidemia is highly prevalent in the Arabian Gulf. Non-high-density lipoprotein cholesterol (non-HDL-C) reduction has been proposed as an additional goal to low-density lipoprotein cholesterol (LDL-C) lowering to prevent atherosclerotic cardiovascular disease (ASCVD). Data on non-HDL-C goal attainment in patients with high triglycerides (TGs) on lipid-lowering drugs (LLDs) in the region is scarce. Objective: Evaluate non-HDL-C target attainment according to the National Lipid Association in patients on LLDs stratified by TG (200 [2.26] mg/dL [mmol/L]) levels in the Arabian Gulf. Methods: Overall, 4383 patients on LLD treatment from 6 Middle Eastern countries participating in the Centralized Pan-Middle East Survey on the Undertreatment of Hypercholesterolemia study were evaluated. Patients were classified according to TG levels and ASCVD risk. Results: The overall non-HDL-C goal attainment was 41% of the subjects. Non-HDL-C goal was less likely attained in patients with high TGs (12% vs 27% vs 55%; P <.001). Very high ASCVD risk patients with high TGs attained less their non-HDL-C targets compared with those with lower TG levels (8% vs 23% vs 51%; P <.001). Similarly, high ASCVD risk patients with high TGs also failed more in attaining non-HDL-C targets compared with those with lower TGs (26% vs 42% vs 69%; P <.001). In addition, those with high TG also succeeded less in attaining LDL-C and apolipoprotein B goals (P <.001). Conclusions: A large proportion of very high and high ASCVD patients on LLDs in the Arabian Gulf are not at recommended non-HDL-C targets and hence remain at a substantial residual risk.

AB - Background: Atherogenic dyslipidemia is highly prevalent in the Arabian Gulf. Non-high-density lipoprotein cholesterol (non-HDL-C) reduction has been proposed as an additional goal to low-density lipoprotein cholesterol (LDL-C) lowering to prevent atherosclerotic cardiovascular disease (ASCVD). Data on non-HDL-C goal attainment in patients with high triglycerides (TGs) on lipid-lowering drugs (LLDs) in the region is scarce. Objective: Evaluate non-HDL-C target attainment according to the National Lipid Association in patients on LLDs stratified by TG (200 [2.26] mg/dL [mmol/L]) levels in the Arabian Gulf. Methods: Overall, 4383 patients on LLD treatment from 6 Middle Eastern countries participating in the Centralized Pan-Middle East Survey on the Undertreatment of Hypercholesterolemia study were evaluated. Patients were classified according to TG levels and ASCVD risk. Results: The overall non-HDL-C goal attainment was 41% of the subjects. Non-HDL-C goal was less likely attained in patients with high TGs (12% vs 27% vs 55%; P <.001). Very high ASCVD risk patients with high TGs attained less their non-HDL-C targets compared with those with lower TG levels (8% vs 23% vs 51%; P <.001). Similarly, high ASCVD risk patients with high TGs also failed more in attaining non-HDL-C targets compared with those with lower TGs (26% vs 42% vs 69%; P <.001). In addition, those with high TG also succeeded less in attaining LDL-C and apolipoprotein B goals (P <.001). Conclusions: A large proportion of very high and high ASCVD patients on LLDs in the Arabian Gulf are not at recommended non-HDL-C targets and hence remain at a substantial residual risk.

KW - Apolipoprotein B

KW - Cardiovascular diseases

KW - Diabetes mellitus

KW - HDL cholesterol

KW - LDL cholesterol

KW - Middle East

KW - Non-HDL cholesterol

KW - Triglycerides

UR - http://www.scopus.com/inward/record.url?scp=84955455386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955455386&partnerID=8YFLogxK

U2 - 10.1016/j.jacl.2015.12.021

DO - 10.1016/j.jacl.2015.12.021

M3 - Article

C2 - 27055968

AN - SCOPUS:84955455386

JO - Journal of Clinical Lipidology

JF - Journal of Clinical Lipidology

SN - 1933-2874

ER -