Nitro-aspirin is a potential therapy for non alcoholic fatty liver disease

Mohamed Ibrahim, Entesar Farghaly, Wafaey Gomaa, Mina Kelleni, Aly Mohamed Abdelrahman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury; however its therapeutic strategy has not been established yet. Nitro-aspirin (NO-aspirin) is a new molecule in which aspirin and a NO-donating group are covalently linked. This study investigated the potential protective effect of NO-aspirin on NAFLD. Experimental rats were assigned into 4 groups. Group 1 was fed with normal diet and served as normal control group. Group 2 was fed with 2% cholesterol diet and received vehicle as positive control NAFLD group. Group 3 was fed with 2% cholesterol diet plus NO-aspirin (100 mg/kg/day). Group 4 was fed with 2% cholesterol diet plus aspirin (55 mg/kg/day). Rats were treated for 8 weeks. The results showed that NO-aspirin (but not aspirin) prevented the development of NAFLD as evidenced by significant reduction in liver weight/body weight ratio (liver index) and histopathologic changes. The protective effect of NO-aspirin is accompanied with significant decrease in triglycerides, malondialdehyde (MDA), and nitric oxide (NO) in hepatic tissue. Semi-quantitative immunohistochemical studies showed significant decrease in expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in hepatic tissue. In conclusion, NO-aspirin inhibited multiple pathways involved in the pathogenesis of NAFLD indicating that it might serve as a new therapeutic strategy.

Original languageEnglish
Pages (from-to)289-295
Number of pages7
JournalEuropean Journal of Pharmacology
Volume659
Issue number2-3
DOIs
Publication statusPublished - Jun 1 2011

Keywords

  • Aspirin
  • NAFLD
  • NO-aspirin

ASJC Scopus subject areas

  • Pharmacology

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