TY - JOUR
T1 - New holistic approach for the management of biofilm-associated infections by myco-metabolites
AU - Ghosh, Sreejita
AU - Nag, Moupriya
AU - Lahiri, Dibyajit
AU - Sarkar, Tanmay
AU - Pati, Siddhartha
AU - Joshi, Sanket
AU - Ray, Rina R.
N1 - Funding Information:
NA
Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022/4/3
Y1 - 2022/4/3
N2 - Biofilm-associated infections have increased excessively over the recent years due to the increased population having impaired immune systems or as a result of certain medical conditions like transplantation, cancer, and any other chronic ailments. The abrupt enhancement of antibiotic resistance and enhanced utilization of biomedical devices offer new opportunities for microbial colonization leading to the development of microbial biofilms. Total eradication of recalcitrant microbial biofilms demands the adoption of a holistic approach and since the fungal metabolites enriched with bioactive compounds show efficacy in inhibiting the multiple factors behind biofilm formation, the anti-biofilm activities of fungal metabolites need to be appraised. Being effective in preventing various steps of biofilm formation, including inhibition of surface adhesion and cell-to-cell communication through quorum quenching, blocking of quorum sensing receptors, and enzymes involved in microbial cell wall biosynthesis, targeting the virulence factors and finally killing of biofilm bound individual cells; myco-metabolites are found effective as a potent holistic anti-biofilm agent. The wide spectrum of bioactive substances of fungi and their anti-biofilm activities against different pathogens and their multitarget characteristics are very promising in the field of treating biofilm infections.
AB - Biofilm-associated infections have increased excessively over the recent years due to the increased population having impaired immune systems or as a result of certain medical conditions like transplantation, cancer, and any other chronic ailments. The abrupt enhancement of antibiotic resistance and enhanced utilization of biomedical devices offer new opportunities for microbial colonization leading to the development of microbial biofilms. Total eradication of recalcitrant microbial biofilms demands the adoption of a holistic approach and since the fungal metabolites enriched with bioactive compounds show efficacy in inhibiting the multiple factors behind biofilm formation, the anti-biofilm activities of fungal metabolites need to be appraised. Being effective in preventing various steps of biofilm formation, including inhibition of surface adhesion and cell-to-cell communication through quorum quenching, blocking of quorum sensing receptors, and enzymes involved in microbial cell wall biosynthesis, targeting the virulence factors and finally killing of biofilm bound individual cells; myco-metabolites are found effective as a potent holistic anti-biofilm agent. The wide spectrum of bioactive substances of fungi and their anti-biofilm activities against different pathogens and their multitarget characteristics are very promising in the field of treating biofilm infections.
KW - alternative therapeutics
KW - anti-biofilm
KW - chronic infection
KW - myco-metabolites
KW - quorum quencher
KW - Biofilms
KW - Quorum Sensing
KW - Virulence Factors/metabolism
KW - Anti-Bacterial Agents/pharmacology
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UR - https://www.mendeley.com/catalogue/512ac9e6-f60a-3f62-be66-682ad3831929/
U2 - 10.1002/jobm.202200047
DO - 10.1002/jobm.202200047
M3 - Review article
C2 - 35373364
AN - SCOPUS:85127431499
SN - 0233-111X
VL - 62
SP - 1291
EP - 1306
JO - Journal of Basic Microbiology
JF - Journal of Basic Microbiology
IS - 11
ER -