New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2

Daniel J. Drucker; Julie Lovshin; Laurie Baggio; Min Nian; Feisal Adatia; Robin P. Boushey; Yuanfang Liu; Jumana Saleh; Bernardo Yusta; Louise Scrocchi

New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2

Daniel J. Drucker^*, Julie Lovshin, Laurie Baggio, Min Nian, Feisal Adatia, Robin P. Boushey, Yuanfang Liu, Jumana Saleh, Bernardo Yusta, Louise Scrocchi

^*Corresponding author for this work

Biochemistry

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).

Original language	English
Pages (from-to)	226-232
Number of pages	7
Journal	Annals of the New York Academy of Sciences
Volume	921
Publication status	Published - 2000

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2. / Drucker, Daniel J.; Lovshin, Julie; Baggio, Laurie; Nian, Min; Adatia, Feisal; Boushey, Robin P.; Liu, Yuanfang; Saleh, Jumana; Yusta, Bernardo; Scrocchi, Louise.

In: Annals of the New York Academy of Sciences, Vol. 921, 2000, p. 226-232.

Research output: Contribution to journal › Article › peer-review

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abstract = "Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).",

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AU - Nian, Min

AU - Adatia, Feisal

AU - Boushey, Robin P.

AU - Liu, Yuanfang

AU - Saleh, Jumana

AU - Yusta, Bernardo

AU - Scrocchi, Louise

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AB - Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).

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New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2

Abstract

ASJC Scopus subject areas

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