TY - JOUR
T1 - New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2
AU - Drucker, Daniel J.
AU - Lovshin, Julie
AU - Baggio, Laurie
AU - Nian, Min
AU - Adatia, Feisal
AU - Boushey, Robin P.
AU - Liu, Yuanfang
AU - Saleh, Jumana
AU - Yusta, Bernardo
AU - Scrocchi, Louise
PY - 2000
Y1 - 2000
N2 - Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).
AB - Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).
UR - http://www.scopus.com/inward/record.url?scp=0034511625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034511625&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2000.tb06970.x
DO - 10.1111/j.1749-6632.2000.tb06970.x
M3 - Article
C2 - 11193827
AN - SCOPUS:0034511625
VL - 921
SP - 226
EP - 232
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -