New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2

Daniel J. Drucker, Julie Lovshin, Laurie Baggio, Min Nian, Feisal Adatia, Robin P. Boushey, Yuanfang Liu, Jumana Saleh, Bernardo Yusta, Louise Scrocchi

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25 Citations (Scopus)

Abstract

Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).

Original languageEnglish
Pages (from-to)226-232
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume921
Publication statusPublished - 2000

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Drucker, D. J., Lovshin, J., Baggio, L., Nian, M., Adatia, F., Boushey, R. P., ... Scrocchi, L. (2000). New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2. Annals of the New York Academy of Sciences, 921, 226-232.