Abstract
Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).
| Original language | English |
|---|---|
| Pages (from-to) | 226-232 |
| Number of pages | 7 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 921 |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2. / Drucker, Daniel J.; Lovshin, Julie; Baggio, Laurie; Nian, Min; Adatia, Feisal; Boushey, Robin P.; Liu, Yuanfang; Saleh, Jumana; Yusta, Bernardo; Scrocchi, Louise.
In: Annals of the New York Academy of Sciences, Vol. 921, 2000, p. 226-232.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2
AU - Drucker, Daniel J.
AU - Lovshin, Julie
AU - Baggio, Laurie
AU - Nian, Min
AU - Adatia, Feisal
AU - Boushey, Robin P.
AU - Liu, Yuanfang
AU - Saleh, Jumana
AU - Yusta, Bernardo
AU - Scrocchi, Louise
PY - 2000
Y1 - 2000
N2 - Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).
AB - Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for β cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).
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M3 - Article
VL - 921
SP - 226
EP - 232
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -