Abstract
The objective of the study is to investigate the anti-snake venom activities of a local plant, Hibiscus aethiopicus L. The H. aethiopicus was dried and extracted with ethanol. Different assays were performed according to standard techniques, to evaluate the plant's acute toxicity and its antivenom activities. The results of evaluating the systemic acute toxicity of the H. aethiopicus extract using "oral and intra-peritoneal" route were normal even at the highest dose (24g/kg) tested. All guinea pigs (n=3) when treated with venoms E. c. sochureki (75g) alone induced acute skin haemorrhage. In contrast, all guinea pigs (n=18) treated with both venom and the plant extract at a concentration between 500 and 1000mg/kg showed no signs of haemorrhage. Moreover, all guinea pigs (n=18) treated with venom and the plant extract below 400mg/kg showed acute skin haemorrhage. All guinea pigs treated with venom E. c. sochureki (75g) alone induced acute skin haemorrhage after both 24 and 32 hours. In contrast, all guinea pigs treated with both venom and the plant extract (administered independently) at concentrations between 500 and 1000mg/kg showed no signs of haemorrhage after 32 hours. However, after 24 hours all tested guinea pigs showed less inhibition (
| Original language | English |
|---|---|
| Article number | 540671 |
| Journal | Evidence-based Complementary and Alternative Medicine |
| Volume | 2012 |
| DOIs | |
| Publication status | Published - 2012 |
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ASJC Scopus subject areas
- Complementary and alternative medicine
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Neutralisation of local haemorrhage induced by the saw-scaled viper Echis carinatus sochureki venom using ethanolic extract of Hibiscus aethiopicus L. / Hasson, S. S.; Al-Balushi, M. S.; Said, E. A.; Habbal, O.; Idris, M. A.; Mothana, R. A A; Sallam, T. A.; Al-Jabri, A. A.
In: Evidence-based Complementary and Alternative Medicine, Vol. 2012, 540671, 2012.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Neutralisation of local haemorrhage induced by the saw-scaled viper Echis carinatus sochureki venom using ethanolic extract of Hibiscus aethiopicus L.
AU - Hasson, S. S.
AU - Al-Balushi, M. S.
AU - Said, E. A.
AU - Habbal, O.
AU - Idris, M. A.
AU - Mothana, R. A A
AU - Sallam, T. A.
AU - Al-Jabri, A. A.
PY - 2012
Y1 - 2012
N2 - The objective of the study is to investigate the anti-snake venom activities of a local plant, Hibiscus aethiopicus L. The H. aethiopicus was dried and extracted with ethanol. Different assays were performed according to standard techniques, to evaluate the plant's acute toxicity and its antivenom activities. The results of evaluating the systemic acute toxicity of the H. aethiopicus extract using "oral and intra-peritoneal" route were normal even at the highest dose (24g/kg) tested. All guinea pigs (n=3) when treated with venoms E. c. sochureki (75g) alone induced acute skin haemorrhage. In contrast, all guinea pigs (n=18) treated with both venom and the plant extract at a concentration between 500 and 1000mg/kg showed no signs of haemorrhage. Moreover, all guinea pigs (n=18) treated with venom and the plant extract below 400mg/kg showed acute skin haemorrhage. All guinea pigs treated with venom E. c. sochureki (75g) alone induced acute skin haemorrhage after both 24 and 32 hours. In contrast, all guinea pigs treated with both venom and the plant extract (administered independently) at concentrations between 500 and 1000mg/kg showed no signs of haemorrhage after 32 hours. However, after 24 hours all tested guinea pigs showed less inhibition (
AB - The objective of the study is to investigate the anti-snake venom activities of a local plant, Hibiscus aethiopicus L. The H. aethiopicus was dried and extracted with ethanol. Different assays were performed according to standard techniques, to evaluate the plant's acute toxicity and its antivenom activities. The results of evaluating the systemic acute toxicity of the H. aethiopicus extract using "oral and intra-peritoneal" route were normal even at the highest dose (24g/kg) tested. All guinea pigs (n=3) when treated with venoms E. c. sochureki (75g) alone induced acute skin haemorrhage. In contrast, all guinea pigs (n=18) treated with both venom and the plant extract at a concentration between 500 and 1000mg/kg showed no signs of haemorrhage. Moreover, all guinea pigs (n=18) treated with venom and the plant extract below 400mg/kg showed acute skin haemorrhage. All guinea pigs treated with venom E. c. sochureki (75g) alone induced acute skin haemorrhage after both 24 and 32 hours. In contrast, all guinea pigs treated with both venom and the plant extract (administered independently) at concentrations between 500 and 1000mg/kg showed no signs of haemorrhage after 32 hours. However, after 24 hours all tested guinea pigs showed less inhibition (
UR - http://www.scopus.com/inward/record.url?scp=84862285305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862285305&partnerID=8YFLogxK
U2 - 10.1155/2012/540671
DO - 10.1155/2012/540671
M3 - Article
VL - 2012
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
SN - 1741-427X
M1 - 540671
ER -