TY - JOUR
T1 - Neuroprotective effect of natural products against Alzheimer's disease
AU - Essa, Musthafa M.
AU - Vijayan, Reshmi K.
AU - Castellano-Gonzalez, Gloria
AU - Memon, Mustaq A.
AU - Braidy, Nady
AU - Guillemin, Gilles J.
N1 - Funding Information:
Acknowledgments The work has been partly supported by The Research Council; Oman (Grant # RC/AGR/FOOD/11/01). This work has been also supported by the Alzheimer’s Association (grant#IIRG-08-89545) and by the Rebecca Cooper foundation (Australia). Dr Nady Braidy is the recipient of an Alzheimer’s Australia Viertel Foundation Postdoctoral Research Fellowship at the University of New South Wales.
PY - 2012/9
Y1 - 2012/9
N2 - Nature has gifted mankind with a plethora of flora-bearing fruits, vegetables and nuts. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease and other neuronal dysfunctions. Accumulated evidence suggests that naturally occurring phyto-compounds, such as polyphenolic antioxidants found in fruits, vegetables, herbs and nuts, may potentially hinder neurodegeneration, and improve memory and cognitive function. Nuts such as walnut have also demonstrated neuroprotective effect against AD. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signalling pathways associated with protein folding and neuroinflammation. The neuroprotective effects of various naturally occurring compounds in AD is evaluating in this review.
AB - Nature has gifted mankind with a plethora of flora-bearing fruits, vegetables and nuts. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease and other neuronal dysfunctions. Accumulated evidence suggests that naturally occurring phyto-compounds, such as polyphenolic antioxidants found in fruits, vegetables, herbs and nuts, may potentially hinder neurodegeneration, and improve memory and cognitive function. Nuts such as walnut have also demonstrated neuroprotective effect against AD. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signalling pathways associated with protein folding and neuroinflammation. The neuroprotective effects of various naturally occurring compounds in AD is evaluating in this review.
KW - Alzheimer's disease
KW - Antioxidant polyphenols
KW - Cell signaling
KW - Natural products
KW - Neuroprotection
UR - http://www.scopus.com/inward/record.url?scp=84866734918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866734918&partnerID=8YFLogxK
U2 - 10.1007/s11064-012-0799-9
DO - 10.1007/s11064-012-0799-9
M3 - Review article
C2 - 22614926
AN - SCOPUS:84866734918
SN - 0364-3190
VL - 37
SP - 1829
EP - 1842
JO - Neurochemical Research
JF - Neurochemical Research
IS - 9
ER -