Near complete resolution of refractory, relapsed, metastatic wilms' tumour in an adolescent with Bevacizumab

Research output: Contribution to journalArticle

Abstract

Wilms' tumour is common among children but rare in adults. Children with Wilms' tumour have better prognosis even when diagnosed at advanced stage. We report the case of an adolescent girl with chemo-resistant metastatic Wilms' tumour treated previously with two lines of chemotherapy. Upon progression on second line chemotherapy, there was a partial response to Bevacizumab based combination chemotherapy in the third line. Patient was referred for high dose chemotherapy and autologous stem cell therapy. The latter could not be achieved. The patient had a relapse 3 months later and succumbed to the disease.

Original languageEnglish
Pages (from-to)S71-S72
JournalJournal of the College of Physicians and Surgeons Pakistan
Volume24
Publication statusPublished - 2014

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Wilms Tumor
Drug Therapy
Cell- and Tissue-Based Therapy
Combination Drug Therapy
Stem Cells
Recurrence
Bevacizumab

Keywords

  • Adolescent
  • Bevacizumab
  • Partial response
  • Wilms' tumour

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Wilms' tumour is common among children but rare in adults. Children with Wilms' tumour have better prognosis even when diagnosed at advanced stage. We report the case of an adolescent girl with chemo-resistant metastatic Wilms' tumour treated previously with two lines of chemotherapy. Upon progression on second line chemotherapy, there was a partial response to Bevacizumab based combination chemotherapy in the third line. Patient was referred for high dose chemotherapy and autologous stem cell therapy. The latter could not be achieved. The patient had a relapse 3 months later and succumbed to the disease.",
keywords = "Adolescent, Bevacizumab, Partial response, Wilms' tumour",
author = "Shiyam Kumar and Burney, {Ikram A.} and Al-Moundhri, {Mansour S.}",
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AU - Kumar, Shiyam

AU - Burney, Ikram A.

AU - Al-Moundhri, Mansour S.

PY - 2014

Y1 - 2014

N2 - Wilms' tumour is common among children but rare in adults. Children with Wilms' tumour have better prognosis even when diagnosed at advanced stage. We report the case of an adolescent girl with chemo-resistant metastatic Wilms' tumour treated previously with two lines of chemotherapy. Upon progression on second line chemotherapy, there was a partial response to Bevacizumab based combination chemotherapy in the third line. Patient was referred for high dose chemotherapy and autologous stem cell therapy. The latter could not be achieved. The patient had a relapse 3 months later and succumbed to the disease.

AB - Wilms' tumour is common among children but rare in adults. Children with Wilms' tumour have better prognosis even when diagnosed at advanced stage. We report the case of an adolescent girl with chemo-resistant metastatic Wilms' tumour treated previously with two lines of chemotherapy. Upon progression on second line chemotherapy, there was a partial response to Bevacizumab based combination chemotherapy in the third line. Patient was referred for high dose chemotherapy and autologous stem cell therapy. The latter could not be achieved. The patient had a relapse 3 months later and succumbed to the disease.

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KW - Partial response

KW - Wilms' tumour

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